ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2013
Genetics of brain structure: contributions from the Vietnam Era Twin Study of Aging.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Greater male than female variability in regional brain structure across the lifespan.Human brain mapping · 2022Pooled it
- The promise of infant MRI in psychiatry: toward a framework for neural network measures in early emotional and behavioral risk identification and new intervention targets.Molecular psychiatry · 2026Review
- History of chronic pain and opioid use is associated with cognitive decline and mild cognitive impairment.Journal of the International Neuropsychological Society : JINS · 2025Article
- Brain reserve in midlife is associated with executive function changes across 12 years.Neurobiology of aging · 2024Article
- A preliminary investigation into cortical structural alterations in adolescents with nonsuicidal self-injury.Psychiatry research. Neuroimaging · 2023Article
- From mother to child: How intergenerational transfer is reflected in similarity of corticolimbic brain structure and mental health.Developmental cognitive neuroscience · 2023Article
- Erectile Function, Sexual Satisfaction, and Cognitive Decline in Men From Midlife to Older Adulthood.The Gerontologist · 2023Article
- Longitudinal trajectories of cortical development in 22q11.2 copy number variants and typically developing controls.Molecular psychiatry · 2022Article
- Shared Genetic Etiology between Cortical Brain Morphology and Tobacco, Alcohol, and Cannabis Use.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Mother-child similarity in brain morphology: A comparison of structural characteristics of the brain's reading network.Developmental cognitive neuroscience · 2022Article
- Progressive cortical and sub-cortical alterations in patients with anti-N-methyl-D-aspartate receptor encephalitis.Journal of neurology · 2022Article
- The Impact of Genes and Environment on Brain Ageing in Males Aged 51 to 72 Years.Frontiers in aging neuroscience · 2022Article
- Lifestyle and the aging brain: interactive effects of modifiable lifestyle behaviors and cognitive ability in men from midlife to old age.Neurobiology of aging · 2021Article
- DREAM : A Toolbox to Decode Rhythms of the Brain System.Neuroinformatics · 2021Article
- Brain cortical and subcortical morphology in adolescents with depression and a history of suicide attempt.Journal of psychiatry & neuroscience : JPN · 2021Article
- Periventricular and deep abnormal white matter differ in associations with cognitive performance at midlife.Neuropsychology · 2021Article
- Maturation of cortical microstructure and cognitive development in childhood and adolescence: A T1w/T2w ratio MRI study.Human brain mapping · 2020Article
- Altered Cortical Thickness-Based Individualized Structural Covariance Networks in Patients with Schizophrenia and Bipolar Disorder.Journal of clinical medicine · 2020Article
- Brain structural covariance networks in obsessive-compulsive disorder: a graph analysis from the ENIGMA Consortium.Brain : a journal of neurology · 2020Article
- Body mass trajectories and cortical thickness in middle-aged men: a 42-year longitudinal study starting in young adulthood.Neurobiology of aging · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Understanding the genetics of neuropsychiatric disorders requires an understanding of the genetics of brain structure and function. The Vietnam Era Twin Study of Aging (VETSA) is a longitudinal behavioral genetic study focused on cognitive and brain aging. Here, we describe basic science work carried out within the VETSA MRI study that provides meaningful contributions toward the study of neuropsychiatric disorders. VETSA produced the first comprehensive assessment of the heritability of cortical and subcortical brain structure sizes, all within the same individuals. We showed that neocortical thickness and surface area are largely genetically distinct. With continuous neocortical thickness maps, we demonstrated regional specificity of genetic influences, and that genetic factors did not conform to traditional regions of interest (ROIs). However, there was some evidence for different genetic factors accounting for different types of cortex, and for genetic relationships across cortical regions corresponding to anatomical and functional connectivity and brain maturation patterns. With continuous neocortical surface area maps, we confirmed the anterior-posterior gradient of genetic influences on cortical area patterning demonstrated in animal models. Finally, we used twin methods to create the first map of cortical ROIs based entirely on genetically informative data. We conclude that these genetically based cortical phenotypes may be more appropriate for genetic studies than traditional ROIs based on structure or function. Our results also suggest that cortical volume-the product of thickness and surface area-is a problematic phenotype for genetic studies because two independent sets of genes may be obscured. Examples supporting the validity of these conclusions are provided.
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