ArticleInflammation2014
Endotoxin tolerance induced by lipopolysaccharides derived from Porphyromonas gingivalis and Escherichia coli: alternations in Toll-like receptor 2 and 4 signaling pathway.
Article in Inflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Pooled it
- Review
- The cost of persistent alarm: temporal transcriptional reprogramming of macrophages from acute activation to chronic immune suppression by day 11.Frontiers in immunology · 2026Article
- Protection against experimental necrotizing enterocolitis by fecal filtrate transfer requires an active donor virome.Gut microbes · 2025Article
- Article
- Modulation of allograft immune responses by Porphyromonas gingivalis lipopolysaccharide administration in a rat model of kidney transplantation.Scientific reports · 2024Article
- Therapeutic and Phytochemical Properties of Thymoquinone Derived fromCurrent drug research reviews · 2024Review
- Lipopolysaccharide fromInternational journal of molecular sciences · 2022Article
- Different expression patterns of inflammatory cytokines induced by lipopolysaccharides from Escherichia coli or Porphyromonas gingivalis in human dental pulp stem cells.BMC oral health · 2022Article
- Placental extracellular vesicles-associated microRNA-519c mediates endotoxin adaptation in pregnancy.American journal of obstetrics and gynecology · 2021Article
- Effects of Endotoxin Tolerance Induced by Porphyromonas gingivalis Lipopolysaccharide on Inflammatory Responses in Neutrophils.Inflammation · 2020Article
- Multiomic immune clockworks of pregnancy.Seminars in immunopathology · 2020Review
- Ligature-induced periodontitis induces systemic inflammation but does not alter acute outcome after stroke in mice.International journal of stroke : official journal of the International Stroke Society · 2020Article
- Macrophage subsets exhibit distinct E. coli-LPS tolerisable cytokines associated with the negative regulators, IRAK-M and Tollip.PloS one · 2019Article
- Anti-inflammatory effects of low-level laser therapy on human periodontal ligament cells: in vitro study.Lasers in medical science · 2018Article
- Compromised inflammatory cytokine response to P. gingivalis LPS by fibroblasts from inflamed human gingiva.Clinical oral investigations · 2018Article
- Tolerance induced by Porphyromonas gingivalis may occur independently of TLR2 and TLR4.PloS one · 2018Article
- SMAD4 is Involved in the Development of Endotoxin Tolerance in Microglia.Cellular and molecular neurobiology · 2016Article
- Effects of Porphyromonas gingivalis LipopolysaccharideTolerized Monocytes on Inflammatory Responses in Neutrophils.PloS one · 2016Article
- Arterial Catheterization and Infection: Toll-like Receptors in Defense against Microorganisms and Therapeutic Implications.Clinical and translational science · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis is a chronic inflammatory disease induced by bacteria. Exposure of the host to periodontal pathogens and their virulence factors induces a hyporesponsive state to subsequent challenge, which is termed endotoxin tolerance. In this experiment, we studied the cytokine production in THP-1 cells upon single or repeated Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide (LPS) or Escherichia coli (E. coli) LPS stimulation by ELISA. In addition, the protein expression profiles of Toll-like receptor 2 (TLR2), TLR4, IL-1 receptor-associated kinase 4 (IRAK4) and IRAK-M and the gene expression changes of Toll-interacting protein (Tollip) and suppressor of cytokine-signaling-1 (SOCS1) were explored to identify possible mechanisms for changes in cytokine secretion. After repeated stimulation with P. gingivalis LPS or E. coli LPS, secretions of TNF-α and IL-1β were decreased significantly compared with those following single challenge, while the levels of IL-10 were increased (p < 0.05). Only comparable levels of IL-8 were confirmed in P. gingivalis LPS-tolerized cells (p > 0.05). In addition, severe downregulation of TLR2 was detected in THP-1 cells retreated with P. gingivalis LPS, and the reduction of TLR4 expression was observed in cells restimulated with E. coli LPS (p < 0.05). Precondition with P. gingivalis LPS or E. coli LPS also led to an enhancement of IRAK-M and SOCS1, while maintaining the expressions of IRAK4 and Tollip. This pattern of cytokine production indicates the different effects of endotoxin tolerance triggered by P. gingivalis LPS and E. coli LPS, which might contribute to limiting inflammatory damage. Moreover, TLR2, TLR4, IRAK-M, and SOCS1 might play important roles in developing tolerance.
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Registered trials
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