ArticleMedical oncology (Northwood, London, England)2013
Expression of TMPRSS4 in patients with salivary adenoid cystic carcinoma: correlation with clinicopathological features and prognosis.
Article in Medical oncology (Northwood, London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- TMPRSS4 as an emerging potential poor prognostic factor for solid tumors: A systematic review and meta-analysis.Oncotarget · 2016Pooled it
- TMPRSS4 Promotes Cell Proliferation and Inhibits Apoptosis in Pancreatic Ductal Adenocarcinoma by Activating ERK1/2 Signaling Pathway.Frontiers in oncology · 2021Article
- Distant Metastases in Patients with Carcinoma of the Major Salivary Glands.Annals of surgical oncology · 2015Article
- TMPRSS4: an emerging potential therapeutic target in cancer.British journal of cancer · 2015Review
- Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although there is growing evidence supporting the hypothesis that TMPRSS4 is linked with cancer susceptibility, the precise role of TMPRSS4 expression in salivary adenoid cystic carcinoma (SACC) is still unknown. The aim of this study was to examine TMPRSS4 expression in SACC and determine its associations with clinicopathological features and survival. TMPRSS4 expression in 125 SACC tissue and adjacent non-cancerous tissues was analyzed by immunohistochemistry and Western blotting. In addition, the correlation of TMPRSS4 expression with clinicopathological variables was evaluated. The prognostic value of TMPRSS4 for overall survival (OS) and disease-free survival (DFS) was determined by Kaplan-Meier estimates, and the significance of differences between curves was evaluated by the log-rank test. We found that high TMPRSS4 expression was predominantly observed in SACC tissues, but not in the adjacent normal salivary gland tissues. High TMPRSS4 expression in SACC tissues was correlated significantly with tumor TNM stage (P = 0.016), lymph node metastasis (P = 0.002) and distant metastasis (P < 0.001). While high TMPRSS4 expression was associated with poor OS (P = 0.019) and DFS (P = 0.031), Cox regression analysis also revealed that TMPRSS4 was an independent predictor of OS and DFS. These findings suggested that TMPRSS4 was involved in the pathogenesis of SACC and might indicate a poor prognosis for SACC patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.