ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
MicroRNA-128 promotes proliferation in osteosarcoma cells by downregulating PTEN.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 66 citations in OpenAlex.
- Review
- NAIF1 suppresses osteosarcoma progression and is regulated by miR-128.Cell biochemistry and function · 2018Article
- Variants in the 14q32 miRNA cluster are associated with osteosarcoma risk in the Spanish population.Scientific reports · 2018Article
- Upregulation of MicroRNA-4262 Targets Kaiso (ZBTB33) to Inhibit the Proliferation and EMT of Cervical Cancer Cells.Oncology research · 2018Article
- Oligonucleotides Targeting Telomeres and Telomerase in Cancer.Molecules (Basel, Switzerland) · 2018Review
- Expression of Micro-RNA 128 and Let-7b in Pediatric Acute Lymphoblastic Leukemia CasesAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Regulatory effects of microRNA‑184 on osteosarcoma via the Wnt/β‑catenin signaling pathway.Molecular medicine reports · 2018Article
- Exploring the molecular mechanisms of osteosarcoma by the integrated analysis of mRNAs and miRNA microarrays.International journal of molecular medicine · 2018Article
- Observational
- Regulatory mechanism of microRNA-128 in osteosarcoma tumorigenesis and evolution through targeting SASH1.Oncology letters · 2018Article
- LncRNA CCAT2 promoted osteosarcoma cell proliferation and invasion.Journal of cellular and molecular medicine · 2018Article
- miR-128 inhibits telomerase activity by targeting TERT mRNA.Oncotarget · 2018Article
- Expression of NF-κB and PTEN in osteosarcoma and its clinical significance.Oncology letters · 2017Article
- MicroRNA-128-3p regulates mitomycin C-induced DNA damage response in lung cancer cells through repressingOncotarget · 2017Article
- miR-1297 regulates neural stem cell differentiation and viability through controlling Hes1 expression.Cell proliferation · 2017Article
- The SNAIL/miR-128 axis regulated growth, invasion, metastasis, and epithelial-to-mesenchymal transition of gastric cancer.Oncotarget · 2017Article
- MicroRNA-379 suppresses osteosarcoma progression by targeting PDK1.Journal of cellular and molecular medicine · 2017Article
- NOVA1 acts as an oncogene in osteosarcoma.American journal of translational research · 2017Article
- CXCR4/RhoA signaling pathway is involved in miR-128-regulated proliferation and apoptosis of human thyroid cancer cells.International journal of clinical and experimental pathology · 2017Article
- Downregulation of miR-301a-3p sensitizes pancreatic cancer cells to gemcitabine treatment via PTEN.American journal of translational research · 2017Article
Corrections and comments
- Retraction · 2017-04-20Compromised Peer Review · Investigation by Journal/Publisher · · Journal published by SAGE starting in 2017
- Retracted
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs are a class of small noncoding RNAs that function as critical gene regulators through targeting mRNAs for translational repression or degradation. Several studies have indicated that abnormal expression of miRNAs occurs frequently in human osteosarcoma. In the present study, we found that miR-128 expression was significantly increased in osteosarcoma tissues compared to adjacent normal tissues. Ectopic overexpression of miR-128 significantly promoted while suppression of miR-128 by its antisense inhibited the proliferation of MG63 and U2OS cells. At the molecular level, our results demonstrated that miR-128 overexpression could repress expression of PTEN by directly targeting PTEN 3'-untranslated region. Consistently, downstream AKT signaling was altered by miR-128 overexpression or knockdown. Therefore, our results suggest that miR-128 plays an important role in the proliferation of human osteosarcoma cells by directly regulation of PTEN/AKT signaling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.