ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2014
Presentation, pathology, and treatment outcome of brain tumors in 172 consecutive children at CURE Children's Hospital of Uganda. The predominance of the visible diagnosis and the uncertainties of epidemiology in sub-Saharan Africa.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Glioma management and outcome in low-middle-income countries: a systematic review.Frontiers in oncology · 2026Pooled it
- Outcomes of Children With Low-Grade Gliomas in Low- and Middle-Income Countries: A Systematic Review.JCO global oncology · 2022Pooled it
- Worldwide Trends in Survival From Common Childhood Brain Tumors: A Systematic Review.Journal of global oncology · 2019Pooled it
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- The top 100 most cited peer-reviewed publications on global neurosurgery: Mapping research trends and gaps over four decades.Acta neurochirurgica · 2026Review
- Barriers to care to pediatric brain tumors in low- and middle-income countries: A proposal for a critical framework.Surgical neurology international · 2026Review
- Surgical outcomes and clinical profile of pediatric brain tumors: A 3-year retrospective analysis.Surgical neurology international · 2026Article
- Descriptive epidemiology and surgical outcomes of intracranial tumors in southwestern uganda: a cross-sectional study.Journal of neuro-oncology · 2025Article
- Childhood cancer survival in low- and middle-income countries and the Global South: emerging evidence and critical gaps from a scoping review of observational studies.EJC paediatric oncology · 2025Review
- Surgical treatment of pediatric low-grade glioma in developing countries.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- Trends in pediatric CNS tumors in Armenia: a multicenter retrospective study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Article
- Pediatric neurosurgical-oncology scope and management paradigms in Sub-Saharan Africa: a collaboration among 7 referral hospitals on the subcontinent.Frontiers in oncology · 2023Article
- Surgical outcomes of pediatric brain tumors in Sub-Saharan Africa: A systematic review.Brain & spine · 2022Review
- Endoscopic third ventriculostomy and choroid plexus cauterization (ETV/CPC) for hydrocephalus of infancy: a technical review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- The landscape of neuro-oncology in East Africa: a review of published records.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Review
- The need for a central brain tumor registry in Africa: A review of central nervous system tumors in Africa from 1960 to 2017.Neuro-oncology practice · 2021Article
- Article
- A Systematic Review of Neurosurgical Care in Low-Income Countries.World neurosurgery: X · 2020Review
- Patterns, treatments, and outcomes of pediatric central nervous system tumors in Sudan: a single institution experience.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectThis study reviews the first operative series of pediatric brain tumors from Uganda, the largest series from Sub-Saharan Africa, and explores the challenges to progress in pediatric neuro-oncology in the region.
methodsThis is a retrospective operative series of brain tumors in 172 children at Cure Children's Hospital of Uganda over 10 years. Demographics, clinical presentation, lesion location, histopathology, operative management, and outcome were investigated. Survival was assessed using Kaplan-Meier method. Log-rank test and p value with Bonferroni correction were used to determine significance of survival differences.
resultsThere were 103 males (59.9 %) and 69 females (40.1 %; mean age at diagnosis 6.5 years with 29 % < 2 years). The most common histologic types were pilocytic astrocytoma (23.2 %), ependymoma (16.3 %), craniopharyngioma (9.9 %), choroid plexus papilloma (9.3 %), and medulloblastoma (8.1 %). Supratentorial tumors (62.2 %) were more common. Symptomatic hydrocephalus predominated at presentation (66.9 %). In 71 (41.3 %), the presentation was macrocephaly or a visible mass. Estimated 5-year survival was 60 %.
conclusionsThe majority of pediatric brain tumors in the region likely go unrecognized. Most that do come to attention have a "visible diagnosis." Unlike operative series from developed countries, information about the incidence, prevalence, and overall burden of disease for different tumor types cannot be deduced from the various operative series reported from limited resource countries because of the selection bias that is unique to this context. Delayed presentation and poor access to adjuvant therapies were important contributors to the high mortality. The epidemiology of pediatric brain tumors in sub-Saharan Africa is obscure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.