ArticleInternational journal of molecular sciences2013
Structural insights into a novel interkingdom signaling circuit by cartography of the ligand-binding sites of the homologous quorum sensing LuxR-family.
Article in International journal of molecular sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Phytochemical Quorum-Sensing Inhibitors Against Bacterial Pathogens: Mechanisms of Action and Translational Challenges.Current issues in molecular biology · 2026Review
- Article
- CerM and Its Antagonist CerN Are New Components of the Quorum Sensing System in Cereibacter sphaeroides, Signaling to the CckA/ChpT/CtrA System.MicrobiologyOpen · 2024Article
- Interkingdom Signaling of the Insect PathogenMicroorganisms · 2023Article
- Identification of Putative Elicitors From Plant Root Exudates Responsible for PsoR Activation in Plant-BeneficialFrontiers in plant science · 2022Article
- LuxR Solos from Environmental Fluorescent Pseudomonads.mSphere · 2021Article
- LuxR Solos in the Plant EndophyteApplied and environmental microbiology · 2020Article
- Phenotypic Heterogeneity of the Insect Pathogen Photorhabdus luminescens: Insights into the Fate of Secondary Cells.Applied and environmental microbiology · 2019Article
- Characterization of the Noncanonical Regulatory and Transporter Genes in Atratumycin Biosynthesis and Production in a Heterologous Host.Marine drugs · 2019Article
- Omics Technologies to Understand Activation of a Biosynthetic Gene Cluster in Micromonospora sp. WMMB235: Deciphering Keyicin Biosynthesis.ACS chemical biology · 2019Article
- Dialkylresorcinols as bacterial signaling molecules.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Studies on synthetic LuxR solo hybrids.Frontiers in cellular and infection microbiology · 2015Article
- XocR, a LuxR solo required for virulence in Xanthomonas oryzae pv. oryzicola.Frontiers in cellular and infection microbiology · 2015Article
- Census of solo LuxR genes in prokaryotic genomes.Frontiers in cellular and infection microbiology · 2015Article
- LuxR solos in Photorhabdus species.Frontiers in cellular and infection microbiology · 2014Article
- Whole genome sequencing and analysis reveal insights into the genetic structure, diversity and evolutionary relatedness of luxI and luxR homologs in bacteria belonging to the Sphingomonadaceae family.Frontiers in cellular and infection microbiology · 2014Article
- The kiwifruit emerging pathogen Pseudomonas syringae pv. actinidiae does not produce AHLs but possesses three luxR solos.PloS one · 2014Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Recent studies have identified a novel interkingdom signaling circuit, via plant signaling molecules, and a bacterial sub-family of LuxR proteins, bridging eukaryotes and prokaryotes. Indeed pivotal plant-bacteria interactions are regulated by the so called Plant Associated Bacteria (PAB) LuxR solo regulators that, although closely related to the quorum sensing (QS) LuxR family, do not bind or respond to canonical quorum sensing N-acyl homoserine lactones (AHLs), but only to specific host plant signal molecules. The large body of structural data available for several members of the QS LuxR family complexed with different classes of ligands (AHLs and other compounds), has been exploited to dissect the cartography of their regulatory domains through structure-based multiple sequence alignments, structural superimposition and a comparative analysis of the contact residues involved in ligand binding. In the absence of experimentally determined structures of members of the PAB LuxR solos subfamily, an homology model of its prototype OryR is presented, aiming to elucidate the architecture of its ligand-binding site. The obtained model, in combination with the cartography of the regulatory domains of the homologous QS LuxRs, provides novel insights into the 3D structure of its ligand-binding site and unveils the probable molecular determinants responsible for differences in selectivity towards specific host plant signal molecules, rather than to canonical QS compounds.
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