ArticleScientific reports2013
Prostaglandin E₂ is critical for the development of niacin-deficiency-induced photosensitivity via ROS production.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Janus Kinase 2/Signal Transducer and Activator of Transcription 3/Cyclooxygenase 2 Signaling Pathway Mediates the Effect of Central Angiotensin II on the Elevation of Rostral Ventrolateral Medulla Prostaglandin EJournal of the American Heart Association · 2025Article
- Enzymatic approaches to nicotinic acid synthesis: recent advances and future prospects.Frontiers in bioengineering and biotechnology · 2025Review
- Quantitative proteomic and phosphoproteomic analysis reveal the relationship between mitochondrial dysfunction and cytoskeletal remodeling in hiPSC-CMs deficient in PINK1.Journal of translational medicine · 2023Article
- Review
- Protective effect ofBioscience of microbiota, food and health · 2023Article
- Pellagra as a differential diagnosis in the confused patient on the acute medical unit.BMJ case reports · 2022Article
- Analysis of real-world data and a mouse model indicates that pirfenidone causes pellagra.ERJ open research · 2022Article
- Association between Vitamin Intake and Chronic Kidney Disease According to a Variant Located Upstream of theNutrients · 2022Article
- Analysis of the gut microbiome to validate a mouse model of pellagra.Bioscience of microbiota, food and health · 2022Article
- The pentose phosphate pathway mediates hyperoxia-induced lung vascular dysgenesis and alveolar simplification in neonates.JCI insight · 2021Article
- Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning in the zebrafish embryo.Nature communications · 2019Article
- Zinc and Skin Disorders.Nutrients · 2018Review
- Clinical and biochemical footprints of inherited metabolic diseases. VI. Metabolic dermatoses.Molecular genetics and metabolismReview
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Authors and funding
16 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pellagra is a photosensitivity syndrome characterized by three "D's": diarrhea, dermatitis, and dementia as a result of niacin deficiency. However, the molecular mechanisms of photosensitivity dermatitis, the hallmark abnormality of this syndrome, remain unclear. We prepared niacin deficient mice in order to develop a murine model of pellagra. Niacin deficiency induced photosensitivity and severe diarrhea with weight loss. In addition, niacin deficient mice exhibited elevated expressions of COX-2 and PGE syntheses (Ptges) mRNA. Consistently, photosensitivity was alleviated by a COX inhibitor, deficiency of Ptges, or blockade of EP4 receptor signaling. Moreover, enhanced PGE2 production in niacin deficiency was mediated via ROS production in keratinocytes. In line with the above murine findings, human skin lesions of pellagra patients confirmed the enhanced expression of Ptges. Niacin deficiency-induced photosensitivity was mediated through EP4 signaling in response to increased PGE2 production via induction of ROS formation.
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