Evidence map›Paper›PMID 24131825›Full record

Trial reportThe Journal of allergy and clinical immunology2014

GLCCI1 rs37973 does not influence treatment response to inhaled corticosteroids in white subjects with asthma.

Louise Hosking, Eugene Bleecker, Soumitra Ghosh, Astrid Yeo, Loretta Jacques, Michael Mosteller, Deborah Meyers

Open access · greenAbstract readLetterMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in The Journal of allergy and clinical immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Heterogeneity of Treatment Response to Asthma.Advances in experimental medicine and biology · 2023
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Asthma Pharmacogenomics: 2015 Update.Current allergy and asthma reports · 2015
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Louise HoskingDepartment of Projects Clinical Platforms and Sciences, GlaxoSmithKline Research and Development, Stevenage, United Kingdom. Electronic address: louise.k.hosking@gsk.com.
Eugene BleeckerCenter for Human Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston-Salem, NC.
Soumitra GhoshDepartment of Projects Clinical Platforms and Sciences, GlaxoSmithKline Research and Development, Upper Merion, Philadelphia, Pa.
Astrid YeoDepartment of Projects Clinical Platforms and Sciences, GlaxoSmithKline Research and Development, Stevenage, United Kingdom.
Loretta JacquesMedicines Development Centre Global Clinical, GlaxoSmithKline Research and Development, Stockley Park, United Kingdom.
Michael MostellerDepartment of Projects Clinical Platforms and Sciences, GlaxoSmithKline Research and Development, Research Triangle Park, NC.
Deborah MeyersCenter for Human Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston-Salem, NC.
GlaxoSmithKline (United Kingdom) · GBGlaxoSmithKline (United States) · USWake Forest University · US

Funding

THE PHARMACOGENETICS OF ASTHMA TREATMENTU01HL065899 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G, WEISS, SCOTT T · 2000 to 2014
$38.5M
Linking Genetics, Genomics and Phenomics to Better Understand Asthma SeverityRC2HL101487 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BLEECKER, EUGENE ROLAND, KAMINSKI, NAFTALI · 2009 to 2010
$3.5M
NHLBI NIH HHS RC2 HL101487NHLBI NIH HHS U01 HL065899NHLBI NIH HHS U01 HL65899
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adrenal Cortex HormonesAdultAndrostadienesAnti-Asthmatic AgentsAsthmaDouble-Blind MethodFemaleFluticasoneForced Expiratory VolumeHumansMaleMiddle AgedPolymorphism, Single NucleotideReceptors, GlucocorticoidWhite PeopleYoung AdultAdrenal Cortex HormonesAndrostadienesAnti-Asthmatic AgentsFluticasonefluticasone furoateGLCCI1 protein, humanReceptors, Glucocorticoid

Identifiers

PMID24131825
PMCPMC3960323
OpenAlexW1981647983

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.