ArticleJournal of virology2014
Alternative reassortment events leading to transmissible H9N1 influenza viruses in the ferret model.
Article in Journal of virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed.
- Air-liquid interface model for influenza aerosol exposureJournal of virology · 2025Article
- Genetic Characterization of Kazakhstan Isolates: Avian Influenza H9N2 Viruses Demonstrate Their Potential to Infect Mammals.Viruses · 2025Article
- Article
- Intra- and inter-host evolution of H9N2 influenza A virus in Japanese quail.Virus evolution · 2022Article
- Review
- Gene Segment Interactions Can Drive the Emergence of Dominant Yet Suboptimal Gene Constellations During Influenza Virus Reassortment.Frontiers in microbiology · 2021Article
- H9 Influenza Viruses: An Emerging Challenge.Cold Spring Harbor perspectives in medicine · 2020Review
- In vivo rescue of recombinant Zika virus from an infectious cDNA clone and its implications in vaccine development.Scientific reports · 2020Article
- FlexibilityJournal of virology · 2019Article
- Identification of Amino Acid Residues Responsible for Inhibition of Host Gene Expression by Influenza A H9N2 NS1 Targeting of CPSF30.Frontiers in microbiology · 2018Article
- Why Do Exceptionally Dangerous Gain-of-Function Experiments in Influenza?Methods in molecular biology (Clifton, N.J.) · 2018Review
- SELECTED EPIDEMICS & EMERGING PATHOGENS.Disease-a-month : DM · 2017Review
- Immune Escape Variants of H9N2 Influenza Viruses Containing Deletions at the Hemagglutinin Receptor Binding Site Retain FitnessJournal of virology · 2017Article
- Pathogenicity of reassortant H9 influenza viruses with different NA genes in mice and chickens.Veterinary research · 2016Article
- A North American H7N3 Influenza Virus Supports Reassortment with 2009 Pandemic H1N1 and Induces Disease in Mice without Prior Adaptation.Journal of virology · 2016Article
- Genetic Adaptation of Influenza A Viruses in Domestic Animals and Their Potential Role in Interspecies Transmission: A Literature Review.EcoHealth · 2016Review
- Influenza A virus transmission via respiratory aerosols or droplets as it relates to pandemic potential.FEMS microbiology reviews · 2016Review
- Replication and transmission of mammalian-adapted H9 subtype influenza virus in pigs and quail.The Journal of general virology · 2015Article
- Influenza A Virus Coinfection through Transmission Can Support High Levels of Reassortment.Journal of virology · 2015Article
- The infection of turkeys and chickens by reassortants derived from pandemic H1N1 2009 and avian H9N2 influenza viruses.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Influenza A H9N2 viruses are common poultry pathogens that occasionally infect swine and humans. It has been shown previously with H9N2 viruses that reassortment can generate novel viruses with increased transmissibility. Here, we demonstrate the modeling power of a novel transfection-based inoculation system to select reassortant viruses under in vivo selective pressure. Plasmids containing the genes from an H9N2 virus and a pandemic H1N1 (pH1N1) virus were transfected into HEK 293T cells to potentially generate the full panel of possible H9 reassortants. These cells were then used to inoculate ferrets, and the population dynamics were studied. Two respiratory-droplet-transmissible H9N1 viruses were selected by this method, indicating a selective pressure in ferrets for the novel combination of surface genes. These results show that a transfection-based inoculation system is a fast and efficient method to model reassortment and highlight the risk of reassortment between H9N2 and pH1N1 viruses.
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