ArticleJournal of clinical microbiology2014
Molecular analysis and clinical significance of Lactobacillus spp. recovered from clinical specimens presumptively associated with disease.
Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Immunosuppression is associated with loss of airway microbiome resilience in severe COVID-19.Microbiome · 2026Article
- Childhood obesity, dietary patterns and gut microbiota: a narrative review.Journal of physiology and biochemistry · 2026Review
- FermentedInternational journal of medical sciences · 2026Article
- Article
- Article
- The joint protective function of live- and dead-Aging · 2024Article
- Advantage of precision metagenomics for urinary tract infection diagnostics.Frontiers in cellular and infection microbiology · 2023Article
- Protective Effects ofEvidence-based complementary and alternative medicine : eCAM · 2023Article
- Organic Acids Secreted byMolecules (Basel, Switzerland) · 2022Article
- Article
- Species-Level Resolution of Female Bladder Microbiota from 16S rRNA Amplicon Sequencing.mSystems · 2021Article
- Detection of Pathogenic Bacteria From Septic Patients Using 16S Ribosomal RNA Gene-Targeted Metagenomic Sequencing.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Connecting the Dots: Translating the Vaginal Microbiome Into a Drug.The Journal of infectious diseases · 2021Article
- Potential ofHeliyon · 2020Article
- Article
- Characterization of a stress tolerance-defective mutant of Lactobacillus rhamnosus LRB.Molecular oral microbiology · 2019Article
- An insight into intestinal mucosal microbiota disruption after stroke.Scientific reports · 2018Article
- A Metabolomics Approach Reveals Immunomodulatory Effects of Proteinaceous Molecules Derived From Gut Bacteria Over Human Peripheral Blood Mononuclear Cells.Frontiers in microbiology · 2018Article
- Scientific Opinion on the update of the list of QPS-recommended biological agents intentionally added to food or feed as notified to EFSA.EFSA journal. European Food Safety Authority · 2017Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lactobacillus spp. are part of the normal human flora and are generally assumed to be nonpathogenic. We determined the genotypic identification of >100 Lactobacillus isolates from clinical specimens in the context of presumed pathogenic potential (e.g., recovered as the single/predominant isolate from a sterile site or at ≥10(5) CFU/ml from urine). This study assessed the clinical significance and the frequency of occurrence of each Lactobacillus sp. We identified 16 species of Lactobacillus by 16S rRNA gene sequence analysis, 10 of which could not be associated with disease. While Lactobacillus rhamnosus, Lactobacillus gasseri, and Lactobacillus paracasei were associated with infections, L. gasseri was also a common colonizing/contaminating species. Lactobacillus casei, Lactobacillus johnsonii, and Lactobacillus delbrueckii were associated with at least one infection. Species commonly used in probiotic products (e.g., L. rhamnosus and L. casei) were identical, by 16S rRNA gene sequencing, to our isolates associated with disease. Human isolates of Lactobacillus spp. have differing site associations and levels of clinical significance. Knowing the niche and pathogenic potential of each Lactobacillus sp. can be of importance to both clinical microbiology and the food and probiotic supplement industry.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.