ArticleBMC complementary and alternative medicine2013
Hypoglycemic effect of polysaccharides with different molecular weight of Pseudostellaria heterophylla.
Article in BMC complementary and alternative medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 86 citations in OpenAlex.
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- Controlled Drug Release from Nanoengineered Polysaccharides.Pharmaceutics · 2023Review
- Comparative Study on the Structural Properties and Bioactivities of Three Different Molecular Weights ofMolecules (Basel, Switzerland) · 2023Article
- Effect of Pseudostellaria heterophylla polysaccharide on the growth and liver metabolism of chicks.Journal of animal science · 2023Article
- Recent advances in the extraction, purification, structural-property correlations, and antiobesity mechanism of traditional Chinese medicine-derived polysaccharides: a review.Frontiers in nutrition · 2023Review
- Polysaccharides from Pseudostellaria heterophylla modulate gut microbiota and alleviate syndrome of spleen deficiency in rats.Scientific reports · 2022Article
- The regulatory effects ofFood science & nutrition · 2022Article
- High-Molecular-Weight Dextran-Type Exopolysaccharide Produced by the NovelInternational journal of molecular sciences · 2022Article
- Effect of crude polysaccharide from seaweed, Dictyopteris divaricata (CDDP) on gut microbiota restoration and anti-diabetic activity in streptozotocin (STZ)-induced T1DM mice.Gut pathogens · 2022Article
- Physicochemical Characteristics and Antidiabetic Properties of the Polysaccharides fromMolecules (Basel, Switzerland) · 2022Article
- Use of Fluorescent 2-AB to Explore the Bidirectional Transport Mechanism ofMolecules (Basel, Switzerland) · 2022Article
- The Potential Role of Cyclopeptides fromMetabolites · 2022Article
- Common Ayurvedic, Chinese traditional and Unani antidiabetic formulations- a review.Frontiers in pharmacology · 2022Review
- Antidiabetic activities of Bolanthus spergulifolius (Caryophyllaceae) extracts on insulin-resistant 3T3-L1 adipocytes.PloS one · 2021Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aims of this study were to evaluate the antidiabetic activity and to detect molecular size of Pseudostellaria heterophylla polysaccharide (PHP). Pseudostellaria heterophylla is a medicine extensively used in traditional Chinese medicine formulas to treat diabetes and its complications.
methodsMolecular weight of PHP was determined by gel permeation chromatography combined with phenol-sulphuric acid method and the monosaccharides composition was determined by HPLC with a precolumn derivatization. Four polysaccharides with different molecular weight were compared for hypoglycemic active on two animal models both high does alloxan induced type1 diabetic mellitus (T1DM) and high-fat/lower does streptozotocin induced type2 diabetic mellitus (T2DM). Blood sugar, glucose tolerance, and insulin tolerance were detected. Rat serum IL-1β, IL-2, IL-10, Leptin, TNF-α, Acrp30 and CRP were also analyzed by sandwich-ELISA approaches to preliminary probe the hypoglycemic mechanism of PHP.
resultsThe hypoglycemic effects related to molecular size of polysaccharide were more effective against T2DM than T1DM. PHP comprise four monosaccharides of galacturonic acid, glucose, galactose and arabinos. T2DM rats daily receiving oral dose of polysaccharide(100 ~ 400 mg/kg) with 50 ~ 210 kDa molecular weight (PF40) could not only significantly lower blood sugar but also reduce total triglyceride level in serum. PF40 improves in insulin tolerance inhibited the expression of some biomarkers including inflammatory cytokine TNF-α and elevated anti-inflammatory cytokine IL-10, regulated adiponectin Acrp30 and leptin.
conclusionsPF40 prevent the cascade of inflammatory events in the treatment of T2DM to block overweight progresses to obesity.
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