ArticleDiabetes technology & therapeutics2014
Improved metabolic control in pediatric patients with type 1 diabetes: a nationwide prospective 12-year time trends analysis.
Article in Diabetes technology & therapeutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Effect of early glycemic control on HbA1c tracking and development of vascular complications after 5 years of childhood onset type 1 diabetes: Systematic review and meta-analysis.Pediatric diabetes · 2019Pooled it
- Closed-loop glucose control in young people with type 1 diabetes during and after unannounced physical activity: a randomised controlled crossover trial.Diabetologia · 2017Trial
- Improving Diabetes Care Through Teamwork, Comprehensive Education, Tighter Goals, and Technology: Single-Center Data from TürkiyeJournal of clinical research in pediatric endocrinology · 2026Article
- Trends in baseline HbA1c and body-mass index in randomised trials of people with type 1 diabetes from 1993 to 2025: an IMI2 SOPHIA systematic review and meta-analysis.EClinicalMedicine · 2025Article
- Impact of COVID-19 lockdown on blood glucose levels in pediatric patients with type 1 diabetes mellitus.Annals of pediatric endocrinology & metabolism · 2025Article
- Attachment in close relationships and glycemic outcomes in children with type 1 diabetes.Child and adolescent psychiatry and mental health · 2023Article
- Effect of the COVID-19 quarantine on metabolic control in children and adolescents with type 1 diabetes.Endocrinologia, diabetes y nutricion · 2022Article
- Sex-Related Differences in Cardiovascular Disease Risk Profile in Children and Adolescents with Type 1 Diabetes.International journal of molecular sciences · 2021Review
- Effect of the COVID-19 quarantine on metabolic control in children and adolescents with type 1 diabetes.Endocrinologia, diabetes y nutricion · 2021Article
- Making Use of Comparable Health Data to Improve Quality of Care and Outcomes in Diabetes: The EUBIROD Review of Diabetes Registries and Data Sources in Europe.Frontiers in clinical diabetes and healthcare · 2021Review
- Temporal trends in diabetic ketoacidosis at diagnosis of paediatric type 1 diabetes between 2006 and 2016: results from 13 countries in three continents.Diabetologia · 2020Article
- Improving Clinical Outcomes in Newly Diagnosed Pediatric Type 1 Diabetes: Teamwork, Targets, Technology, and Tight Control-The 4T Study.Frontiers in endocrinology · 2020Review
- Using insulin pump with a remote-control system in young patients with diabetes improves glycemic control and enhances patient satisfaction.Clinical diabetes and endocrinology · 2019Article
- Dual Role ofFrontiers in pediatrics · 2019Article
- Clinically meaningful and lasting HbADiabetologia · 2018Article
- Continuous subcutaneous insulin infusion in diabetes: patient populations, safety, efficacy, and pharmacoeconomics.Diabetes/metabolism research and reviews · 2016Review
- The Stricter the Better? The Relationship between Targeted HbA1c Values and Metabolic Control of Pediatric Type 1 Diabetes Mellitus.Journal of diabetes research · 2016Review
- Protocol for systematic review of evidence on the determinants and influence of early glycaemic control in childhood-onset type 1 diabetes.Systematic reviews · 2015Article
- Fifty-Five Years of Pediatric Endocrinology and 50 Years of the Department of Pediatric Endocrinology, Diabetes and Metabolic Diseases in Slovenia.Zdravstveno varstvo · 2015Article
- Type 1 Diabetes in the Young: Organization of Two National Centers in Israel and Slovenia.Zdravstveno varstvo · 2015Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study estimated temporal trends of metabolic control over 12 years in a national cohort of childhood-onset type 1 diabetes. SUBJECTS AND
methodsData from the prospective childhood-onset diabetes register, which included 886 case subjects from 0 to 17.99 years of age at diagnosis and at least 1 year of follow-up until the age of 22.99 years, were analyzed using multivariable linear and logistic regression models in the observational period between 2000 and 2011.
resultsHemoglobin A1c (HbA1c) significantly decreased over 12 years, from 78 mmol/mol (interquartile range [IQR], 68-88 mmol/mol) (9.26% [IQR, 8.41-10.24%]) in the year 2000 to 61 mmol/mol (IQR, 55-67 mmol/mol) (7.75% [IQR, 7.20-8.30%]) in the year 2011 (P<0.001). HbA1c was significantly associated with age, treatment modality, and duration of diabetes (P<0.001), with females having on average 1.02% higher HbA1c (P=0.01; 95% confidence interval [CI] 1.005-1.035). The overall use of insulin pumps was 74%. The incidence rate of severe acute complications was low: 1.07 per 100 patient-years for severe diabetic ketoacidosis (95% CI 0.81-1.40) and 1.21 per 100 patient-years for severe (requiring intravenous or intramuscular therapy) hypoglycemia (95% CI 0.81-1.40).
conclusionsThe metabolic control of the entire nationwide pediatric type 1 diabetes population significantly improved during the 12-year observational period with a low rate of severe acute complications events. The improvement was associated with the treatment modality. Additional efforts and solutions are necessary to further improve metabolic control and the quality of life of young people with type 1 diabetes.
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