ArticleThe New England journal of medicine2013
TREM2 and neurodegenerative disease.
Abstract readLetter
In one paragraph
Article in The New England journal of medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Proof-of-concept recall-by-genotype study of extremely low and high Alzheimer's polygenic risk reveals autobiographical deficits and cingulate cortex correlates.Alzheimer's research & therapy · 2023Article
- Microglia: A pharmacological target for the treatment of age-related cognitive decline and Alzheimer's disease.Frontiers in pharmacology · 2023Review
- Emerging Alzheimer's disease therapeutics: promising insights from lipid metabolism and microglia-focused interventions.Frontiers in aging neuroscience · 2023Review
- TREM2 risk variants are associated with atypical Alzheimer's disease.Acta neuropathologica · 2022Article
- Reduced TREM2 activation in microglia of patients with Alzheimer's disease.FEBS open bio · 2021Article
- Targeting innate immunity to protect and cure Alzheimer's disease: opportunities and pitfalls.Molecular psychiatry · 2021Review
- TrendyGenes, a computational pipeline for the detection of literature trends in academia and drug discovery.Scientific reports · 2021Article
- Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition.Journal of neuroinflammation · 2020Article
- FAM222A encodes a protein which accumulates in plaques in Alzheimer's disease.Nature communications · 2020Article
- Associations between rare microglia-linked Alzheimer's disease risk variants and subcortical brain volumes in young individuals.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Article
- TREM2 in Neurodegenerative Diseases.Molecular neurodegeneration · 2017Review
- ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide.NeuroImage · 2017Review
- Alzheimer Disease and Its Growing Epidemic: Risk Factors, Biomarkers, and the Urgent Need for Therapeutics.Neurologic clinics · 2016Review
- Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer's disease cohorts.Scientific reports · 2016Article
- The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume.Neurobiology of aging · 2016Article
- Genetic and Transcriptomic Profiles of Inflammation in Neurodegenerative Diseases: Alzheimer, Parkinson, Creutzfeldt-Jakob and Tauopathies.International journal of molecular sciences · 2016Review
- Genes associated with Alzheimer's disease: an overview and current status.Clinical interventions in aging · 2016Review
- Genetics ignite focus on microglial inflammation in Alzheimer's disease.Molecular neurodegeneration · 2015Review
- The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2015Article
- Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2015Review
Corrections and comments
- Commented on by
Authors and funding
3 authors.
Priya Rajagopalan
Derrek P Hibar
Paul M Thompson
Funding
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0MUC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3MUCLA ALZHEIMERS DISEASE RESEARCH CENTERP50AG016570 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BREDESEN, DALE E. · 1999 to 2014
$25.9MTR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1MAlzheimer's disease risk analyzed using population imaging genomicsR01AG040060 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2011 to 2016
$2.5MPredicting Brain Changes in HIV/AIDSR01NS080655 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NAVIA, BRADFORD, THOMPSON, PAUL M · 2012 to 2015
$2.3MA Multidimensional Alzheimer's Disease Brain AtlasR01EB008281 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMPSON, PAUL M · 2007 to 2010
$1.4MEmpowering Personalized Medicine: Integrating Imaging, Genetics, and BiomarkersR01MH097268 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COPPOLA, GIOVANNI, THOMPSON, PAUL M · 2012 to 2014
$1.3M"MR Morphometrics and Cognitive Decline Rate in Large-Scale Aging Studies"K01AG030514 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CARMICHAEL, OWEN T. · 2008 to 2012
$495kNIA NIH HHS AG016570NIA NIH HHS AG040060NIA NIH HHS K01 AG030514NIA NIH HHS P30 AG010129NIA NIH HHS P50 AG016570NIA NIH HHS R01 AG040060NIA NIH HHS U01 AG024904NIBIB NIH HHS EB008281NIBIB NIH HHS EB015922NIBIB NIH HHS P41 EB015922NIBIB NIH HHS R01 EB008281NIMH NIH HHS MH097268NIMH NIH HHS R01 MH097268NINDS NIH HHS NS080655NINDS NIH HHS R01 NS080655
Abstract
PubMed holds no abstract for this paper.
Indexed as
MutationAgedAlzheimer DiseaseAtrophyBrainFemaleHumansMaleMembrane GlycoproteinsNeurodegenerative DiseasesOrgan SizeReceptors, ImmunologicRiskMembrane GlycoproteinsReceptors, ImmunologicTREM2 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.