ArticlePloS one2013
Amyloid beta(1-40)-induced astrogliosis and the effect of genistein treatment in rat: a three-dimensional confocal morphometric and proteomic study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Lactocaseibacillus-deglycosylated isoflavones prevent Aβ 40-induced Alzheimer's disease in a rat model.AMB Express · 2024Article
- Phytochemicals as Substances that Affect Astrogliosis and their Implications for the Management of Neurodegenerative Diseases.Current medicinal chemistry · 2024Review
- Hippocampal glial inflammatory markers are differentially altered in a novel mouse model of perimenopausal cerebral amyloid angiopathy.Frontiers in aging neuroscience · 2023Article
- Amelioration of amyloid beta (AβIranian journal of basic medical sciences · 2023Article
- Review
- Potential of flavonoids as anti-Alzheimer's agents: bench to bedside.Environmental science and pollution research international · 2022Review
- Digital Reconstruction of the Neuro-Glia-Vascular Architecture.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Beneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model.Drug design, development and therapy · 2020Article
- Soybean isoflavone ameliorates cognitive impairment, neuroinflammation, and amyloid β accumulation in a rat model of Alzheimer's disease.Environmental science and pollution research international · 2019Article
- Trigonelline protects hippocampus against intracerebral Aβ(1-40) as a model of Alzheimer's disease in the rat: insights into underlying mechanisms.Metabolic brain disease · 2019Article
- Emerging Signal Regulating Potential of Genistein Against Alzheimer's Disease: A Promising Molecule of Interest.Frontiers in cell and developmental biology · 2019Review
- Genistein Loaded Nanofibers Protect Spinal Cord Tissue Following Experimental Injury in Rats.Biomedicines · 2018Article
- Molecular and Therapeutic Targets of Genistein in Alzheimer's Disease.Molecular neurobiology · 2017Review
- Genistein protects against AβBMC neuroscience · 2017Article
- Protocol for Three-dimensional Confocal Morphometric Analysis of Astrocytes.Journal of visualized experiments : JoVE · 2015Article
- Genistein, the Isoflavone in Soybean, Causes Amyloid Beta Peptide Accumulation in Human Neuroblastoma Cell Line: Implications in Alzheimer's Disease.Aging and disease · 2015Article
- Selective vasopressin-1a receptor antagonist prevents brain edema, reduces astrocytic cell swelling and GFAP, V1aR and AQP4 expression after focal traumatic brain injury.Brain research · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Astrocytes are highly involved in regulation and homeostasis of the extracellular environment in the healthy brain. In pathological conditions, these cells play a major role in the inflammatory response seen in CNS tissues, which is called reactive astrogliosis and includes hypertrophy and proliferation of astrocytes. Here, we performed 3D confocal microscopy to evaluate the morphological response of reactive astrocytes positive for glial fibrillary acidic protein (GFAP) in rats, to the presence of Aβ(1-40) in the rat brain before and after treatment with genistein. In 50 astrocytes per animal, we measured the volume and surface area for the nucleus, cell body, the entire cell, the tissue covered by single astrocytes and quantified the number and length of branches, the density of the astrocytes and the intensity of GFAP immunoreactivity. Injecting Aβ(1-40) into the brain of rats caused astrogliosis indicated by increased values for all measured parameters. Mass spectrometric analysis of hippocampal tissue in Aβ(1-40)-injected brain showed decreased amounts of tubulins, enolases and myelin basic protein, and increased amounts of dihydropyrimidinase-related protein 2. In Aβ(1-40)-injected rats pretreated with genistein, GFAP intensity was decreased to the sham-operated group level, and Aβ(1-40)-induced astrogliosis was significantly ameliorated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.