SynthesisPloS one2013
Risk of chromosomal abnormalities in early spontaneous abortion after assisted reproductive technology: a meta-analysis.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Differences of Sex Development: A Study of 420 Patients from a Single Tertiary Pediatric Endocrinology Center.Children (Basel, Switzerland) · 2025Article
- Early pregnancy loss rate in first-time fresh cycles of low prognosis patients according to the POSEIDON criteria: a single-center data analysis.Reproductive biology and endocrinology : RB&E · 2025Article
- Embryoscopy and targeted embryo biopsy for the management of early abortion.Journal of assisted reproduction and genetics · 2025Article
- Association of maternal risk factors with fetal aneuploidy and the accuracy of prenatal aneuploidy screening: a correlation analysis based on 12,186 karyotype reports.BMC pregnancy and childbirth · 2023Article
- A chromosomal microarray analysis-based laboratory algorithm for the detection of genetic etiology of early pregnancy loss.Frontiers in genetics · 2023Article
- Non-invasive Prenatal Testing in Pregnancies Following Assisted Reproduction.Current genomics · 2022Review
- Trisomy 21 and Assisted Reproductive Technologies: A review.JBRA assisted reproduction · 2022Review
- Comprehensive analysis of early pregnancy loss based on cytogenetic findings from a tertiary referral center.Molecular cytogenetics · 2021Article
- Application of chromosomal microarray analysis in products of miscarriage.Molecular cytogenetics · 2018Article
- Adverse Effect of Superovulation Treatment on Maturation, Function and Ultrastructural Integrity of Murine Oocytes.Molecules and cells · 2017Article
- A Higher Ovarian Response after Stimulation for IVF Is Related to a Higher Number of Euploid Embryos.BioMed research international · 2017Article
- Chromosome distribution of early miscarriages with present or absent embryos: female predominance.Journal of assisted reproduction and genetics · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies on the risk of chromosomal abnormalities in early spontaneous abortion after assisted reproductive technology (ART) are relatively controversial and insufficient. Thus, to obtain a more precise evaluation of the risk of embryonic chromosomal abnormalities in first-trimester miscarriage after ART, we performed a meta-analysis of all available case-control studies relating to the cytogenetic analysis of chromosomal abnormalities in first-trimester miscarriage after ART.
methodsLiterature search in the electronic databases MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) based on the established strategy. Meta-regression, subgroup analysis, and Galbraith plots were conducted to explore the sources of heterogeneity.
resultsA total of 15 studies with 1,896 cases and 1,186 controls relevant to the risk of chromosomal abnormalities in first- trimester miscarriage after ART, and 8 studies with 601 cases and 602 controls evaluating frequency of chromosome anomaly for maternal age≥35 versus <35 were eligible for the meta-analysis. No statistical difference was found in risk of chromosomally abnormal miscarriage compared to natural conception and the different types of ART utilized, whereas the risk of fetal aneuploidy significantly increased with maternal age≥35 (OR 2.88, 95% CI: 1.74-4.77).
conclusionsART treatment does not present an increased risk for chromosomal abnormalities occurring in a first trimester miscarriage, but incidence of fetal aneuploidy could increase significantly with advancing maternal age.
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