ArticlePloS one2013
Comprehensive clinic-pathological characteristics of cervical cancer in southwestern China and the clinical significance of histological type and lymph node metastases in young patients.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 15 citations in OpenAlex.
- Risk and prognosis for brain metastasis in primary metastatic cervical cancer patients: A population-based study.Open medicine (Warsaw, Poland) · 2025Article
- The outcomes and quality of life of young patients undergoing adjuvant radiotherapy versus non-radiotherapy following surgery treating early FIGO stage cervical squamous cell cancer in southwestern China.Scientific reports · 2020Article
- Mortality from cervical cancer in Brazil: an ecological epidemiologic study of a 22-year analysis.Ecancermedicalscience · 2020Article
- Stage and histology of cervical cancer in women under 25 years old.Journal of gynecologic oncology · 2019Article
- Cervical cancer in women aged 25 years or younger: a retrospective study.Cancer management and research · 2019Article
- GINS2 is a novel prognostic biomarker and promotes tumor progression in early-stage cervical cancer.Oncology reports · 2017Article
- Development and validation of a surgical-pathologic staging and scoring system for cervical cancer.Oncotarget · 2016Article
- Article
- Clinicopathological Features and Survival of Adolescent and Young Adults with Cervical Cancer.Cancer control : journal of the Moffitt Cancer CenterArticle
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6 authors at 2 institutions in 1 country.
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Abstract
objectiveTo analyze the clinic-pathological characteristics of women with cervical cancers in southwestern China and discuss the features and prognosis of young patients.
methodsA retrospective study was performed, which consisted of 1,543 patients diagnosed with cervical cancer and underwent treatment at West China Second University Hospital between November 2005 and December 2010. Among them, 154 young patients with surgical procedures between November 2005 and December 2008 were selected for a 5-year follow-up and prognostic analysis.
resultsThe proportion of advanced FIGO stage in patients aged over 35 years was higher than in patients aged 35 years or younger (55.1% vs 38.8%, P<0.001), and strong correlation was found between FIGO stages and the postoperative pathological risk factors (P<0.05). 312 patients (20.2%) were under 35 years old in the last 5 years. The proportion of cervical adenocarcinoma remained high in young patients (13.6%), and young women with adenocarcinoma had a higher rate of LN metastases, comparing with those with squamous cell carcinoma (42.9% vs 15.8%, P = 0.004). Young patients with adenocarcinoma had shorter progression-free survival than those who had squamous cell carcinoma (P = 0.024). Patients aged 35 years or younger with positive postoperative pathological risk factors had shorter progression-free survival, comparing with those with negative factors (P<0.01).
conclusionPatients over 35 years were preliminarily diagnosed as advanced FIGO stage and they were more likely to have deep stromal invasion, LVSI, LN metastases, parametrial and surgical margin involvement. Regarding to young patients, cervical adenocarcinoma increased the risk of LN metastases and positive postoperative pathological risk factors could apparently worsen the prognosis. Histological type and LN metastases were independent prognostic factors for young patients in southwestern China. We re-emphasize the importance of health education and regular smear screening for elder women, and more attention should be paid to young patients with adenocarcinoma or LN metastases.
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