ArticlePloS one2013
A prospective epidemiological study of acute mountain sickness in Nepalese pilgrims ascending to high altitude (4380 m).
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Sex-based differences in the prevalence of acute mountain sickness: a meta-analysis.Military Medical Research · 2019Pooled it
- Association between smoking and the risk of acute mountain sickness: a meta-analysis of observational studies.Military Medical Research · 2016Pooled it
- Smartwatch-Based Maximum Oxygen Consumption Measurement for Predicting Acute Mountain Sickness: Diagnostic Accuracy Evaluation Study.JMIR mHealth and uHealth · 2023Trial
- Sex differences in cardiorespiratory control under hypoxia: the roles of oxygen desaturation and hypoxic exposure time.Frontiers in cardiovascular medicine · 2025Article
- Sleep Quality Among Pilgrims at High Altitude: A Cross-Sectional Study From Gosaikunda Lake, Nepal (4380 m).Cureus · 2024Article
- Recent advances in predicting acute mountain sickness: from multidimensional cohort studies to cutting-edge model applications.Frontiers in physiology · 2024Review
- Counter-gradient variation and the expensive tissue hypothesis explain parallel brain size reductions at high elevation in cricetid and murid rodents.Scientific reports · 2023Article
- High-altitude illness: Menace in Himalayas of Nepal.Annals of medicine and surgery (2012) · 2022Article
- Article
- Physiological responses during ascent to high altitude and the incidence of acute mountain sickness.Physiological reports · 2021Article
- Differences in Tolerance to Hypoxia: Physiological, Biochemical, and Molecular-Biological Characteristics.Biomedicines · 2020Review
- Systematic Review of the Effects of Phosphodiesterase-5 Inhibitors and Dexamethasone on High Altitude Pulmonary Edema (HAPE).Spartan medical research journal · 2019Review
- The Role of Salivary miR-134-3p and miR-15b-5p as Potential Non-invasive Predictors for Not Developing Acute Mountain Sickness.Frontiers in physiology · 2019Article
- Acute mountain sickness (AMS) in a Nepali pilgrim after rapid ascent to a sacred lake (4380 m) in the Himalayas.BMJ case reports · 2018Article
- A Signature of Circulating microRNAs Predicts the Susceptibility of Acute Mountain Sickness.Frontiers in physiology · 2017Article
- Incidence and severity of acute mountain sickness and associated symptoms in children trekking on Xue Mountain, Taiwan.PloS one · 2017Observational
- IL-10 Dysregulation in Acute Mountain Sickness Revealed by Transcriptome Analysis.Frontiers in immunology · 2017Article
- Diagnosis and prediction of the occurrence of acute mountain sickness measuring oxygen saturation--independent of absolute altitude?Sleep & breathing = Schlaf & Atmung · 2016Article
- Impact of rapid ascent to high altitude on sleep.Sleep & breathing = Schlaf & Atmung · 2015Article
- Effect of hypobaric hypoxia on cognitive functions and potential therapeutic agents.The Malaysian journal of medical sciences : MJMS · 2014Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEach year, thousands of pilgrims travel to the Janai Purnima festival in Gosainkunda, Nepal (4380 m), ascending rapidly and often without the aid of pharmaceutical prophylaxis.
methodsDuring the 2012 Janai Purnima festival, 538 subjects were recruited in Dhunche (1950 m) before ascending to Gosainkunda. Through interviews, subjects provided demographic information, ratings of AMS symptoms (Lake Louise Scores; LLS), ascent profiles, and strategies for prophylaxis.
resultsIn the 491 subjects (91% follow-up rate) who were assessed upon arrival at Gosainkunda, the incidence of AMS was 34.0%. AMS was more common in females than in males (RR = 1.57; 95% CI = 1.23, 2.00), and the AMS incidence was greater in subjects >35 years compared to subjects ≤35 years (RR = 1.63; 95% CI = 1.36, 1.95). There was a greater incidence of AMS in subjects who chose to use garlic as a prophylactic compared to those who did not (RR = 1.69; 95% CI = 1.26, 2.28). Although the LLS of brothers had a moderate correlation (intraclass correlation = 0.40, p = 0.023), sibling AMS status was a weak predictor of AMS.
conclusionsThe incidence of AMS upon reaching 4380 m was 34% in a large population of Nepalese pilgrims. Sex, age, and ascent rate were significant factors in the development of AMS, and traditional Nepalese remedies were ineffective in the prevention of AMS.
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