ArticlePloS one2013
Distinguishing ichthyoses by protein profiling.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Clinical vs. chronological skin age: exploring determinants and stratum corneum protein markers of differential skin ageing in 351 healthy women.Scientific reports · 2024Article
- The Epidermal Transcriptome Analysis of a Novel c.639_642dupInternational journal of molecular sciences · 2023Article
- Ichthyosis vulgaris: An updated review.Skin health and disease · 2023Review
- Protein profiling of forehead epidermal corneocytes distinguishes frontal fibrosing from androgenetic alopecia.PloS one · 2023Article
- Towards Precision Dermatology: Emerging Role of Proteomic Analysis of the Skin.Dermatology (Basel, Switzerland) · 2022Review
- Loricrin: Past, Present, and Future.International journal of molecular sciences · 2020Review
- Co-Occurrence of Autosomal Recessive Lamellar Ichthyosis and X-Linked Recessive Ichthyosis in a Consanguineous Pakistani Family.Annals of dermatology · 2019Article
- Review
- Cornification of nail keratinocytes requires autophagy for bulk degradation of intracellular proteins while sparing components of the cytoskeleton.Apoptosis : an international journal on programmed cell death · 2019Article
- Differential Evolution of the Epidermal Keratin Cytoskeleton in Terrestrial and Aquatic Mammals.Molecular biology and evolution · 2019Article
- Corneocyte proteomics: Applications to skin biology and dermatology.Experimental dermatology · 2018Review
- Embryonic AP1 Transcription Factor Deficiency Causes a Collodion Baby-Like Phenotype.The Journal of investigative dermatology · 2017Article
- Proteomic profiling of Pachyonychia congenita plantar callus.Journal of proteomics · 2017Article
- An IL-17-dominant immune profile is shared across the major orphan forms of ichthyosis.The Journal of allergy and clinical immunology · 2017Article
- A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.The Journal of cell biology · 2015Article
- Gene expression profiling in pachyonychia congenita skin.Journal of dermatological science · 2015Article
- Structural and biochemical changes underlying a keratoderma-like phenotype in mice lacking suprabasal AP1 transcription factor function.Cell death & disease · 2015Article
- Human hair shaft proteomic profiling: individual differences, site specificity and cuticle analysis.PeerJ · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
To explore the usefulness of protein profiling for characterization of ichthyoses, we here determined the profile of human epidermal stratum corneum by shotgun proteomics. Samples were analyzed after collection on tape circles from six anatomic sites (forearm, palm, lower leg, forehead, abdomen, upper back), demonstrating site-specific differences in profiles. Additional samples were collected from the forearms of subjects with ichthyosis vulgaris (filaggrin (FLG) deficiency), recessive X-linked ichthyosis (steroid sulfatase (STS) deficiency) and autosomal recessive congenital ichthyosis type lamellar ichthyosis (transglutaminase 1 (TGM1) deficiency). The ichthyosis protein expression patterns were readily distinguishable from each other and from phenotypically normal epidermis. In general, the degree of departure from normal was lower from ichthyosis vulgaris than from lamellar ichthyosis, parallel to the severity of the phenotype. Analysis of samples from families with ichthyosis vulgaris and concomitant modifying gene mutations (STS deficiency, GJB2 deficiency) permitted correlation of alterations in protein profile with more complex genetic constellations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.