ArticleDental research journal2013
Management of oral submucous fibrosis by two different drug regimens: A comparative study.
Article in Dental research journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Interventions for managing oral submucous fibrosis.The Cochrane database of systematic reviews · 2024Pooled it
- Anti-Fibrotic MicroRNA-Based Intervention in Oral Submucous Fibrosis: A Scoping Review.International journal of dentistry · 2026Review
- Oral submucous fibrosis: pathogenesis and therapeutic approaches.International journal of oral science · 2025Review
- Oral submucosal fibrosis: a comprehensive review on pathogenesis, diagnosis, therapeutics and computational advances.Frontiers in cell and developmental biology · 2025Review
- Efficacy of colchicine in oral submucous fibrosis: A systematic review and meta-analysis.Bioinformation · 2025Article
- Colchicine in the Management of Oral Submucous Fibrosis - A Systematic Review and GRADE Assessment.Journal of pharmacy & bioallied sciences · 2024Article
- Colchicine in the Management of Oral Submucous Fibrosis: A Systematic Review, Meta-analysis, and GRADE-Based Assessment of Certainty of Evidence.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Drug treatment for oral submucous fibrosis: an update.BMC oral health · 2023Review
- In-vitro analysis on the potential use of dental pulp mesenchymal stem cells on arecoline-induced oral epithelial cells.Medical oncology (Northwood, London, England) · 2022Article
- Potential Application of an Aqueous Extract ofMaterials (Basel, Switzerland) · 2021Article
- Research Achievements of Oral Submucous Fibrosis: Progress and Prospect.BioMed research international · 2021Review
- Oral submucous fibrosis: a contemporary narrative review with a proposed inter-professional approach for an early diagnosis and clinical management.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2020Review
- Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy.International journal of molecular sciences · 2019Review
- Comparison of Therapeutic Efficacy of Placental Extract with Dexamethasone and Hyaluronic Acid with Dexamethasone for Oral Submucous Fibrosis - A Retrospective Analysis.Journal of clinical and diagnostic research : JCDR · 2016Article
- Article
- Efficacy of oral colchicine with intralesional hyaluronidase or triamcinolone acetonide in the Grade II oral submucous fibrosis.National journal of maxillofacial surgeryArticle
- Efficiency of platelet-rich plasma in management of oral lichen planus: a systematic review and meta-analysis.Revista cientifica odontologica (Universidad Cientifica del Sur)Review
- Medical management of oral submucous fibrosis.Asia-Pacific journal of oncology nursingArticle
- A novel clinical protocol for therapeutic intervention in oral submucous fibrosis: An evidence based approach.Journal of oral and maxillofacial pathology : JOMFPReview
- Medicinal management of oral submucous fibrosis in the past decade- A systematic review.Journal of oral biology and craniofacial researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOral Submucous Fibrosis (OSF) is a precancerous condition of the oral mucosa. Existing treatments give only temporary symptomatic relief. Colchicine is an ancient drug with anti-fibrotic and anti-inflammatory properties. We planned to study the effects of colchicine in the management of oral submucous fibrosis. MATERIALS AND
methodsFifty OSF patients were divided randomly into two groups and treated for 12 weeks. Group 1-Patients were administered tablet colchicine orally, 0.5 mg twice daily and 0.5 ml intralesional injection Hyaluronidase 1,500 IU into each buccal mucosa once a week. Group 2-Patients were administered 0.5 ml intralesional injection Hyaluronidase 1,500 IU and 0.5 ml intralesional injection Hydrocortisone acetate 25 mg/ml in each buccal mucosa once a week alternatively. Student's t test and analysis of variance (ANOVA) were used to compare pre and post treatment results. P<0.05 was considered as significant.
resultsThirty-three percent in group 1 got relief from burning sensation in the second week. Inter group comparisons of increase in mouth opening and reduction in histological parameters indicated that group 1 patients responded better than group 2.
conclusionThese encouraging results should prompt further clinical trials with colchicine alone on a larger sample size to broaden the therapeutic usefulness of the drug in the management of OSF.
Indexed as
Identifiers
24130591PMC3793419W59572107What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.