ReviewFrontiers in immunology2013
The many faces of aire in central tolerance.
Review in Frontiers in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Post-Aire Medullary Thymic Epithelial Cells and Hassall's Corpuscles as Inducers of Tonic Pro-Inflammatory Microenvironment.Frontiers in immunology · 2021Article
- Review
- T-cell receptor affinity in the age of cancer immunotherapy.Molecular carcinogenesis · 2020Review
- Decreased expression of circulating Aire and increased Tfh/Tfr cells in myasthenia gravis patients.Bioscience reports · 2018Article
- Aire controls the recirculation of murine Foxp3European journal of immunology · 2018Article
- Comparison of Burnet's clonal selection theory with tumor cell-clone development.Theranostics · 2018Article
- Twenty Years of AIRE.Frontiers in immunology · 2018Review
- A key role for IL-7R in the generation of microenvironments required for thymic dendritic cells.Immunology and cell biology · 2017Article
- Thymic NF-κB-inducing kinase regulates CD4Journal of hepatology · 2017Article
- Thymic Germinal Centers and Corticosteroids in Myasthenia Gravis: an Immunopathological Study in 1035 Cases and a Critical Review.Clinical reviews in allergy & immunology · 2017Review
- Medullary thymic epithelial cells and CD8αJournal of autoimmunity · 2016Article
- FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator).The Journal of biological chemistry · 2016Article
- Hormonal control of T-cell development in health and disease.Nature reviews. Endocrinology · 2016Review
- Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes.Nature genetics · 2015Article
- Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy.Journal of clinical immunology · 2015Review
- Molecular mimicry and clonal deletion: A fresh look.Journal of theoretical biology · 2015Article
- Medullary thymic epithelial cells and central tolerance in autoimmune hepatitis development: novel perspective from a new mouse model.International journal of molecular sciences · 2015Review
- The Thymic Orchestration Involving Aire, miRNAs, and Cell-Cell Interactions during the Induction of Central Tolerance.Frontiers in immunology · 2015Review
- Editorial: The Role of Aire, microRNAs and Cell-Cell Interactions on Thymic Architecture and Induction of Tolerance.Frontiers in immunology · 2015Article
- Immunological considerations in in utero hematopoetic stem cell transplantation (IUHCT).Frontiers in pharmacology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the role that Autoimmune Regulator (Aire) plays in the induction of central tolerance is well known, the precise cellular and molecular mechanisms are still unclear and debated. In the prevailing view, Aire serves mainly as a direct inducer of tissue-specific antigens. However, there is a growing amount of evidence suggesting that Aire modulates the differentiation program of medullary thymic epithelial cells, which may directly contribute to the negative selection of self-reactive thymocytes. In addition, Aire has been shown to regulate the expression of many intrathymic chemokines that are required for the proper localization of thymocytes and dendritic cells, and thus are potentially important for direct and indirect self-antigen presentation in the thymic medulla. Further, recent evidence suggests that the induction of certain antigen-specific regulatory T-cells that translocate to tumors and peripheral tissues can be Aire dependent and may contribute to tissue-specific tolerance. This review summarizes the current understanding of the effects of Aire on these alternative mechanisms for the induction of Aire-induced central tolerance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.