ArticleFrontiers in endocrinology2013
Developmental profile and sexually dimorphic expression of kiss1 and kiss1r in the fetal mouse brain.
Article in Frontiers in endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Sex difference in developmental changes in visualized Kiss1 neurons in newly generated Kiss1-Cre rats.The Journal of reproduction and development · 2023Article
- Sexual Dimorphism in Kisspeptin Signaling.Cells · 2022Review
- The role of Kisspeptin signaling in Oocyte maturation.Frontiers in endocrinology · 2022Review
- A recessive PRDM13 mutation results in congenital hypogonadotropic hypogonadism and cerebellar hypoplasia.The Journal of clinical investigation · 2021Article
- Biological Significance of Kisspeptin-Kiss 1 Receptor Signaling in the Habenula of Teleost Species.Frontiers in endocrinology · 2018Review
- Kisspeptin innervation of the hypothalamic paraventricular nucleus: sexual dimorphism and effect of estrous cycle in female mice.Journal of anatomy · 2017Article
- Excess Testosterone Exposure Alters Hypothalamic-Pituitary-Testicular Axis Dynamics and Gene Expression in Sheep Fetuses.Endocrinology · 2016Article
- Hypothalamic control of the male neonatal testosterone surge.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- The Influence of Gonadal Steroid Hormones on Immunoreactive Kisspeptin in the Preoptic Area and Arcuate Nucleus of Developing Agonadal Mice with a Genetic Disruption of Steroidogenic Factor 1.Neuroendocrinology · 2016Article
- Kisspeptin Activates Ankrd 26 Gene Expression in Migrating Embryonic GnRH Neurons.Frontiers in endocrinology · 2016Article
- Rbpj-κ mediated Notch signaling plays a critical role in development of hypothalamic Kisspeptin neurons.Developmental biology · 2015Article
- Sexual differentiation of the brain requires perinatal kisspeptin-GnRH neuron signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Murine arcuate nucleus kisspeptin neurons communicate with GnRH neurons in utero.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- RFamide Peptides in Early Vertebrate Development.Frontiers in endocrinology · 2014Review
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
The hypothalamic-pituitary-gonadal axis (HPG) is a complex neuroendocrine circuit involving multiple levels of regulation. Kisspeptin neurons play essential roles in controlling the HPG axis from the perspectives of puberty onset, oscillations of gonadotropin releasing hormone (GnRH) neuron activity, and the pre-ovulatory LH surge. The current studies focus on the expression of kisspeptin during murine fetal development using in situ hybridization (ISH), quantitative reverse transcription real-time PCR (QPCR), and immunocytochemistry. Expression of mRNA coding for kisspeptin (KISS1) and its receptor KISS1R was observed at embryonic (E) day 13 by ISH. At E13 and other later ages examined, Kiss1 signal in individual cells within the arcuate nucleus (ARC) appeared stronger in females than males. ISH examination of agonadal steroidogenic factor-1 (Sf1) knockout mice revealed that E17 XY knockouts (KO) resembled wild-type (WT) XX females. These findings raise the possibility that gonadal hormones modulate the expression of Kiss1 in the ARC prior to birth. The sex and genotype differences were tested quantitatively by QPCR experiments in dissected hypothalami from mice at E17 and adulthood. Females had significantly more Kiss1 than males at both ages, even though the number of cells detected by ISH was similar. In addition, QPCR revealed a significant difference in the amount of Kiss1 mRNA in Sf1 mice with WT XY mice expressing less than XY KO and XX mice of both genotypes. The detection of immunoreactive KISS1 in perikarya of the ARC at E17 indicates that early mRNA is translated to peptide. The functional significance of this early expression of Kiss1 awaits elucidation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.