ArticleFrontiers in endocrinology2013
Blood-Based Indicators of Insulin Resistance and Metabolic Syndrome in Bottlenose Dolphins (Tursiops truncatus).
Article in Frontiers in endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 58 citations in OpenAlex.
- Proteomic Characterization of Bottlenose Dolphin (Journal of proteome research · 2026Article
- Identification of insulin and glucagon genes in the finless porpoise and the developmental distribution of their producing endocrine cells.Frontiers in endocrinology · 2026Article
- Assessing Bottlenose Dolphins' (Animals : an open access journal from MDPI · 2025Article
- Aging-Associated Amyloid-β Plaques and Neuroinflammation in Bottlenose Dolphins (International journal of molecular sciences · 2025Article
- Targeted Nutritional Metabolomic Analysis of Marine Species (Tursiops truncatus, Phoca vitulina, Otaria flavescens and Pygoscelis papua).Veterinary medicine and science · 2025Article
- An update on captive cetacean welfare.PeerJ · 2025Review
- Immunolocalization of Two Neurotrophins, NGF and BDNF, in the Pancreas of the South American Sea LionAnimals : an open access journal from MDPI · 2024Article
- Review
- A time-series analysis of blood-based biomarkers within a 25-year longitudinal dolphin cohort.PLoS computational biology · 2023Article
- Comparative genomics of cetartiodactyla: energy metabolism underpins the transition to an aquatic lifestyle.Conservation physiology · 2021Article
- Circulating concentrations of thyroid hormones and cortisol in wild and semi-natural Yangtze finless porpoise (Conservation physiology · 2021Article
- Animal models of naturally occurring stone disease.Nature reviews. Urology · 2020Review
- Effects of sex, age, and season on the variation of blood analytes in a clinically healthyThe veterinary quarterly · 2020Article
- A 25-y longitudinal dolphin cohort supports that long-lived individuals in same environment exhibit variation in aging rates.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Possible dysmetabolic hyperferritinemia in hyperinsulinemic horses.Open veterinary journal · 2020Article
- Article
- Characterization of Insulin and Glucagon Genes and Their Producing Endocrine Cells From Pygmy Sperm Whale (Frontiers in endocrinology · 2020Article
- New de novo assembly of the Atlantic bottlenose dolphin (Tursiops truncatus) improves genome completeness and provides haplotype phasing.GigaScience · 2019Article
- Molecular Footprints of Aquatic Adaptation Including Bone Mass Changes in Cetaceans.Genome biology and evolution · 2018Article
- The Case Study of Nesfatin-1 in the Pancreas ofFrontiers in physiology · 2018Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Similar to people with metabolic syndrome, bottlenose dolphins (Tursiops truncatus) can have a sustained postprandial hyperglycemia and hyperinsulinemia, dyslipidemia, and fatty liver disease. A panel of potential postprandial blood-based indicators of insulin resistance and metabolic syndrome were compared among 34 managed collection dolphins in San Diego Bay, CA, USA (Group A) and 16 wild, free-ranging dolphins in Sarasota Bay, FL, USA (Group B). Compared to Group B, Group A had higher insulin (2.1 ± 2.5 and 13 ± 13 μIU/ml), glucose (87 ± 19 and 108 ± 12 mg/dl), and triglycerides (75 ± 28 and 128 ± 45 mg/dl) as well as higher cholesterol (total, high-density lipoprotein cholesterol, and very low density lipoprotein cholesterol), iron, transferrin saturation, gamma-glutamyl transpeptidase (GGT), alanine transaminase, and uric acid. Group A had higher percent unmodified adiponectin. While Group A dolphins were older, the same blood-based differences remained when controlling for age. There were no differences in body mass index (BMI) between the groups, and comparisons between Group B and Group A dolphins have consistently demonstrated lower stress hormones levels in Group A. Group A dolphins with high insulin (greater than 14 μIU/ml) had higher glucose, iron, GGT, and BMI compared to Group A dolphins with lower insulin. These findings support that some dolphin groups may be more susceptible to insulin resistance compared to others, and primary risk factors are not likely age, BMI, or stress. Lower high-molecular weight adiponectin has been identified as an independent risk factor for type 2 diabetes in humans and may be a target for preventing insulin resistance in dolphins. Future investigations with these two dolphin populations, including dietary and feeding differences, may provide valuable insight for preventing and treating insulin resistance in humans.
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