ArticlePLoS pathogens2013
Regulation of innate responses during pre-patent schistosome infection provides an immune environment permissive for parasite development.
Article in PLoS pathogens, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Innate immune receptors are differentially expressed in mice during experimental Schistosoma mansoni early infection.Memorias do Instituto Oswaldo Cruz · 2024Article
- Pulmonary inflammation promoted by type-2 dendritic cells is a feature of human and murine schistosomiasis.Nature communications · 2023Article
- Schistosoma mansoni egg-derived extracellular vesicles: A promising vaccine candidate against murine schistosomiasis.PLoS neglected tropical diseases · 2021Article
- Strongyloides stercoralis and HTLV-1 coinfection in CD34+ cord blood stem cell humanized mice: Alteration of cytokine responses and enhancement of larval growth.PLoS neglected tropical diseases · 2021Article
- Interleukin (IL)-33 is dispensable for Schistosoma mansoni worm maturation and the maintenance of egg-induced pathology in intestines of infected mice.Parasites & vectors · 2021Article
- Interleukin-4 Signaling Plays a Major Role in Urogenital Schistosomiasis-Associated Bladder Pathogenesis.Infection and immunity · 2020Article
- Role of T lymphocytes and papain enzymatic activity in the protection induced by the cysteine protease againstJournal of advanced research · 2019Article
- A secreted schistosome cathepsin B1 cysteine protease and acute schistosome infection induce a transient T helper 17 response.PLoS neglected tropical diseases · 2019Article
- TRP channels as potential targets for antischistosomals.International journal for parasitology. Drugs and drug resistance · 2018Review
- Host- and Helminth-Derived Endocannabinoids That Have Effects on Host Immunity Are Generated during Infection.Infection and immunity · 2018Article
- Hematopoietic cell-derived RELMα regulates hookworm immunity through effects on macrophages.Journal of leukocyte biology · 2018Article
- Atypical pharmacology of schistosome TRPA1-like ion channels.PLoS neglected tropical diseases · 2018Article
- Host Adaptive Immune Status Regulates Expression of the Schistosome AMP-Activated Protein Kinase.Frontiers in immunology · 2018Article
- Schistosome Egg Migration: Mechanisms, Pathogenesis and Host Immune Responses.Frontiers in immunology · 2018Review
- High throughput data analyses of the immune characteristics of Microtus fortis infected with Schistosoma japonicum.Scientific reports · 2017Article
- TRP channels in schistosomes.International journal for parasitology. Drugs and drug resistance · 2016Review
- Eosinophils and IL-4 Support Nematode Growth Coincident with an Innate Response to Tissue Injury.PLoS pathogens · 2015Article
- Article
- I-L-C-2 it: type 2 immunity and group 2 innate lymphoid cells in homeostasis.Current opinion in immunology · 2014Review
- Induction of protective immune responses against schistosomiasis using functionally active cysteine peptidases.Frontiers in genetics · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Blood flukes of the genus Schistosoma infect over 200 million people, causing granulomatous pathology with accompanying morbidity and mortality. As a consequence of extensive host-parasite co-evolution, schistosomes exhibit a complex relationship with their hosts, in which immunological factors are intimately linked with parasite development. Schistosomes fail to develop normally in immunodeficient mice, an outcome specifically dependent on the absence of CD4⁺ T cells. The role of CD4⁺ T cells in parasite development is indirect and mediated by interaction with innate cells, as repeated toll-like receptor 4 stimulation is sufficient to restore parasite development in immunodeficient mice in the absence of CD4⁺ T cells. Here we show that repeated stimulation of innate immunity by an endogenous danger signal can also restore parasite development and that both these stimuli, when administered repeatedly, lead to the regulation of innate responses. Supporting a role for regulation of innate responses in parasite development, we show that regulation of inflammation by neutralizing anti-TNF antibodies also restores parasite development in immunodeficient mice. Finally, we show that administration of IL-4 to immunodeficient mice to regulate inflammation by induction of type 2 responses also restores parasite development. These findings suggest that the type 2 response driven by CD4⁺ T cells during pre-patent infection of immunocompetent hosts is exploited by schistosomes to complete their development to reproductively mature adult parasites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.