ArticlePLoS computational biology2013
A simple rule for dendritic spine and axonal bouton formation can account for cortical reorganization after focal retinal lesions.
Article in PLoS computational biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers.
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40 citing papers in PubMed, 88 citations in OpenAlex.
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- On the Role of the Excitation/Inhibition Balance of Homeostatic Artificial Neural Networks.Entropy (Basel, Switzerland) · 2021Article
- Growth rules for the repair of Asynchronous Irregular neuronal networks after peripheral lesions.PLoS computational biology · 2021Article
- Adaptive Rewiring in Weighted Networks Shows Specificity, Robustness, and Flexibility.Frontiers in systems neuroscience · 2021Article
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- The road ahead in clinical network neuroscience.Network neuroscience (Cambridge, Mass.) · 2019Review
- Network remodeling induced by transcranial brain stimulation: A computational model of tDCS-triggered cell assembly formation.Network neuroscience (Cambridge, Mass.) · 2019Article
- Multicontact Co-operativity in Spike-Timing-Dependent Structural Plasticity Stabilizes Networks.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Associative properties of structural plasticity based on firing rate homeostasis in recurrent neuronal networks.Scientific reports · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lasting alterations in sensory input trigger massive structural and functional adaptations in cortical networks. The principles governing these experience-dependent changes are, however, poorly understood. Here, we examine whether a simple rule based on the neurons' need for homeostasis in electrical activity may serve as driving force for cortical reorganization. According to this rule, a neuron creates new spines and boutons when its level of electrical activity is below a homeostatic set-point and decreases the number of spines and boutons when its activity exceeds this set-point. In addition, neurons need a minimum level of activity to form spines and boutons. Spine and bouton formation depends solely on the neuron's own activity level, and synapses are formed by merging spines and boutons independently of activity. Using a novel computational model, we show that this simple growth rule produces neuron and network changes as observed in the visual cortex after focal retinal lesions. In the model, as in the cortex, the turnover of dendritic spines was increased strongest in the center of the lesion projection zone, while axonal boutons displayed a marked overshoot followed by pruning. Moreover, the decrease in external input was compensated for by the formation of new horizontal connections, which caused a retinotopic remapping. Homeostatic regulation may provide a unifying framework for understanding cortical reorganization, including network repair in degenerative diseases or following focal stroke.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.