ArticlePLoS medicine2013
Pregnancy weight gain and childhood body weight: a within-family comparison.
Article in PLoS medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Maternal weight gain in pregnancy and risk of obesity among offspring: a systematic review.Journal of obesity · 2014Pooled it
- Effectiveness and Cost-Effectiveness of a Cluster-Randomized Prenatal Lifestyle Counseling Trial: A Seven-Year Follow-Up.PloS one · 2016Trial
- Maternal Body Mass Index, Gestational Weight Gain, and Cardiovascular Disease in Offspring.JAMA network open · 2026Article
- Investigating the relationship between environmental air pollution exposure and abnormal gestational weight gain in twin pregnancies: a retrospective study.Journal of endocrinological investigation · 2026Article
- Ethnicity modifies the relationship between added sugars and fructose exposure in the first 1000 days and offspring body composition at 24 months.Nutrition research (New York, N.Y.) · 2025Article
- Maternal glucose homeostasis during pregnancy in women with overweight or obesity and offspring metabolic health.Scientific reports · 2024Article
- Maternal Body Mass Index and Recommended Gestational Weight Gain in a Middle Eastern Setting.Maternal and child health journal · 2024Article
- Maternal cardiovascular disorders before and during pregnancy and offspring cardiovascular risk across the life course.Nature reviews. Cardiology · 2023Review
- Obesity is related to maternal periodontitis severity in pregnancy: a cross-sectional study.Clinical oral investigations · 2023Article
- Gestational weight gain in women with pre-pregnancy overweight or obesity and anthropometry of infants at birth.Frontiers in pediatrics · 2023Article
- The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support the brain.Frontiers in nutrition · 2023Article
- Microbiome-immune-metabolic axis in the epidemic of childhood obesity: Evidence and opportunities.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2020Review
- Gestational Exercise and Maternal and Child Health: Effects until Delivery and at Post-Natal Follow-up.Journal of clinical medicine · 2020Article
- Evaluation of Maternal Dietary n-3 LCPUFA Supplementation as a Primary Strategy to Reduce Offspring Obesity: Lessons From the INFAT Trial and Implications for Future Research.Frontiers in nutrition · 2020Article
- Effect of Lifestyle Interventions in Obese Pregnant Women on the Neurocognitive Development and Anthropometrics of Preschool Children.Obesity facts · 2020Article
- Women's recall of health care provider counselling on gestational weight gain (GWG): a prospective, population-based study.BMC pregnancy and childbirth · 2019Article
- Is the Association Between Pregnancy Weight Gain and Fetal Size Causal?: A Re-examination Using a Sibling Comparison Design.Epidemiology (Cambridge, Mass.) · 2019Observational
- 90th Anniversary Commentary: Obesity among Offspring of US Immigrants: After 20 Years, a Need to Safeguard Children from the Obesogenic Environment.The Journal of nutrition · 2018Article
- Diagnosis, treatment and prevention of pediatric obesity: consensus position statement of the Italian Society for Pediatric Endocrinology and Diabetology and the Italian Society of Pediatrics.Italian journal of pediatrics · 2018Review
- Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundExcessive pregnancy weight gain is associated with obesity in the offspring, but this relationship may be confounded by genetic and other shared influences. We aimed to examine the association of pregnancy weight gain with body mass index (BMI) in the offspring, using a within-family design to minimize confounding. METHODS AND
findingsIn this population-based cohort study, we matched records of all live births in Arkansas with state-mandated data on childhood BMI collected in public schools (from August 18, 2003 to June 2, 2011). The cohort included 42,133 women who had more than one singleton pregnancy and their 91,045 offspring. We examined how differences in weight gain that occurred during two or more pregnancies for each woman predicted her children's BMI and odds ratio (OR) of being overweight or obese (BMI≥85th percentile) at a mean age of 11.9 years, using a within-family design. For every additional kg of pregnancy weight gain, childhood BMI increased by 0.0220 (95% CI 0.0134-0.0306, p<0.0001) and the OR of overweight/obesity increased by 1.007 (CI 1.003-1.012, p = 0.0008). Variations in pregnancy weight gain accounted for a 0.43 kg/m(2) difference in childhood BMI. After adjustment for birth weight, the association of pregnancy weight gain with childhood BMI was attenuated but remained statistically significant (0.0143 kg/m(2) per kg of pregnancy weight gain, CI 0.0057-0.0229, p = 0.0007).
conclusionsHigh pregnancy weight gain is associated with increased body weight of the offspring in childhood, and this effect is only partially mediated through higher birth weight. Translation of these findings to public health obesity prevention requires additional study. Please see later in the article for the Editors' Summary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.