ArticleGenetics and molecular biology2013
Identification of candidate genes for lung cancer somatic mutation test kits.
Article in Genetics and molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Exploring the protective role of maternal lung cancer history on allergic rhinitis.Journal of clinical biochemistry and nutrition · 2025Article
- Clinical relevance of stem cells in lung cancer.World journal of stem cells · 2023Review
- DEGBOE: Discrete time Evolution modeling of Gene mutation through Bayesian inference using qualitative Observation of mutation Events.Journal of biomedical informatics · 2022Article
- Next-Generation Sequencing in Lung Cancer Patients: A Comparative Approach in NSCLC and SCLC Mutational Landscapes.Journal of personalized medicine · 2022Article
- Review
- Analysis of targeted somatic mutations in pleomorphic carcinoma of the lung using next-generation sequencing technique.Thoracic cancer · 2020Article
- Advancements in next-generation sequencing for diagnosis and treatment of non-small-cell lung cancer.Chronic diseases and translational medicine · 2017Article
- Presence of cancer-associated mutations in exhaled breath condensates of healthy individuals by next generation sequencing.Oncotarget · 2017Article
- Improved Classification of Lung Cancer Using Radial Basis Function Neural Network with Affine Transforms of Voss Representation.PloS one · 2015Article
- Lung cancer prediction using neural network ensemble with histogram of oriented gradient genomic features.TheScientificWorldJournal · 2015Article
- Mutations of EGFR or KRAS and expression of chemotherapy-related genes based on small biopsy samples in stage IIIB and IV inoperable non-small cell lung cancer.Journal of cancer research and clinical oncology · 2014Article
- Unraveling tumor grading and genomic landscape in lung neuroendocrine tumors.Endocrine pathology · 2014Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the past three decades, mortality from lung cancer has sharply and continuously increased in China, ascending to the first cause of death among all types of cancer. The ability to identify the actual sequence of gene mutations may help doctors determine which mutations lead to precancerous lesions and which produce invasive carcinomas, especially using next-generation sequencing (NGS) technology. In this study, we analyzed the latest lung cancer data in the COSMIC database, in order to find genomic "hotspots" that are frequently mutated in human lung cancer genomes. The results revealed that the most frequently mutated lung cancer genes are EGFR, KRAS and TP53. In recent years, EGFR and KRAS lung cancer test kits have been utilized for detecting lung cancer patients, but they presented many disadvantages, as they proved to be of low sensitivity, labor-intensive and time-consuming. In this study, we constructed a more complete catalogue of lung cancer mutation events including 145 mutated genes. With the genes of this list it may be feasible to develop a NGS kit for lung cancer mutation detection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.