ArticleThe Journal of cell biology1985
The complement of desmosomal plaque proteins in different cell types.
Article in The Journal of cell biology, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 191 citations in OpenAlex.
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- Against the rules: human keratin K80: two functional alternative splice variants, K80 and K80.1, with special cellular localization in a wide range of epithelia.The Journal of biological chemistry · 2010Article
- The intercellular organization of the two muscular systems in the adult salmonid heart, the compact and the spongy myocardium.Journal of anatomy · 2009Article
- Discovering the molecular components of intercellular junctions--a historical view.Cold Spring Harbor perspectives in biology · 2009Review
- Plakoglobin suppresses epithelial proliferation and hair growth in vivo.The Journal of cell biology · 2000Article
- Sinus-lining cells of the lymph nodes recognized as a dendritic cell type by the new monoclonal antibody Ki-M9.The American journal of pathology · 1997Article
- Characterization of epithelial primary cultures from human conjunctiva.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 1997Article
- Characterization of pinin, a novel protein associated with the desmosome-intermediate filament complex.The Journal of cell biology · 1996Article
- Symplekin, a novel type of tight junction plaque protein.The Journal of cell biology · 1996Article
- Breaking the connection: displacement of the desmosomal plaque protein desmoplakin from cell-cell interfaces disrupts anchorage of intermediate filament bundles and alters intercellular junction assembly.The Journal of cell biology · 1996Article
- The binding of plakoglobin to desmosomal cadherins: patterns of binding sites and topogenic potential.The Journal of cell biology · 1996Article
- Continual assembly of half-desmosomal structures in the absence of cell contacts and their frustrated endocytosis: a coordinated Sisyphus cycle.The Journal of cell biology · 1995Article
- Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes.The Journal of cell biology · 1995Article
- Protein zero, a nervous system adhesion molecule, triggers epithelial reversion in host carcinoma cells.The Journal of cell biology · 1995Article
- Contactus adherens, a special type of plaque-bearing adhering junction containing M-cadherin, in the granule cell layer of the cerebellar glomerulus.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Identification of amino acid sequence motifs in desmocollin, a desmosomal glycoprotein, that are required for plakoglobin binding and plaque formation.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Identification of the plakoglobin-binding domain in desmoglein and its role in plaque assembly and intermediate filament anchorage.The Journal of cell biology · 1994Article
- Epidermolysis bullosa herpetiformis (Dowling-Meara type) exhibits ultrastructural derangement of tonofilaments and desmosomes.Archives of dermatological research · 1994Article
- Functional analysis of desmoplakin domains: specification of the interaction with keratin versus vimentin intermediate filament networks.The Journal of cell biology · 1993Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Desmosomal plaque proteins have been identified in immunoblotting and immunolocalization experiments on a wide range of cell types from several species, using a panel of monoclonal murine antibodies to desmoplakins I and II and a guinea pig antiserum to desmosomal band 5 protein. Specifically, we have taken advantage of the fact that certain antibodies react with both desmoplakins I and II, whereas others react only with desmoplakin I, indicating that desmoplakin I contains unique regions not present on the closely related desmoplakin II. While some of these antibodies recognize epitopes conserved between chick and man, others display a narrow species specificity. The results show that proteins whose size, charge, and biochemical behavior are very similar to those of desmoplakin I and band 5 protein of cow snout epidermis are present in all desmosomes examined. These include examples of simple and pseudostratified epithelia and myocardial tissue, in addition to those of stratified epithelia. In contrast, in immunoblotting experiments, we have detected desmoplakin II only among cells of stratified and pseudostratified epithelial tissues. This suggests that the desmosomal plaque structure varies in its complement of polypeptides in a cell-type specific manner. We conclude that the obligatory desmosomal plaque proteins, desmoplakin I and band 5 protein, are expressed in a coordinate fashion but independently from other differentiation programs of expression such as those specific for either epithelial or cardiac cells.
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