ArticleThe Journal of cell biology1985
alpha-Internexin, a 66-kD intermediate filament-binding protein from mammalian central nervous tissues.
Article in The Journal of cell biology, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 101 citations in OpenAlex.
- Alpha-internexin as a brain-specific neurodegeneration marker: development and validation of a novel CSF assay.Journal of neurology · 2025Article
- Posttranscriptional regulation of neurofilament proteins and tau in health and disease.Brain research bulletin · 2023Review
- Neurofilaments and Neurofilament Proteins in Health and Disease.Cold Spring Harbor perspectives in biology · 2017Review
- Spatial memory impairment by TRPC1 depletion is ameliorated by environmental enrichment.Oncotarget · 2016Article
- Expression pattern of neuronal intermediate filament α-internexin in anterior pituitary gland and related tumors.Pituitary · 2015Article
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- Intermediate filaments: a historical perspective.Experimental cell research · 2007Review
- Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Neurodegeneration with features of NIFID and ALS--extended clinical and neuropathological spectrum.Brain pathology (Zurich, Switzerland) · 2006Article
- Axonally transported peripheral signals regulate alpha-internexin expression in regenerating motoneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Formation of intermediate filament protein aggregates with disparate effects in two transgenic mouse models lacking the neurofilament light subunit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Late onset of motor neurons in mice overexpressing wild-type peripherin.The Journal of cell biology · 1999Article
- Neurofilament and intermediate filament immunoreactivity in human intestinal myenteric neurons.Digestive diseases and sciences · 1997Article
- The predicted amino acid sequence of alpha-internexin is that of a novel neuronal intermediate filament protein.The EMBO journal · 1990Article
- Cytoskeleton-associated plectin: in situ localization, in vitro reconstitution, and binding to immobilized intermediate filament proteins.The Journal of cell biology · 1988Article
- Monoclonal antibody analysis of keratin expression in the central nervous system.Proceedings of the National Academy of Sciences of the United States of America · 1987Article
- beta-Internexin, a ubiquitous intermediate filament-associated protein.The Journal of cell biology · 1985Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In this paper we describe a 66-kD protein that co-purifies with intermediate filaments from rat optic nerve and spinal cord but can be separated further by ion-exchange chromatography. This protein is distinct from the 68-kD neurofilament subunit protein as judged by isoelectric focusing, immunoblotting, peptide mapping, and tests of polymerization competence. This protein is avidly recognized by the monoclonal anti-intermediate filament antigen antibody, previously demonstrated to recognize a common antigenic determinant in all five known classes of intermediate filaments. Also, when isolated this protein binds to various intermediate filament subunit proteins, which suggests an in vivo interaction with the intermediate filament cytoskeleton, and it appears to be axonally transported in the rat optic nerve. Because of this ability to bind to intermediate filaments in situ and in vitro we have named this protein alpha-internexin. A possible functional role for the protein in organizing filament assembly and distribution is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.