ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2014
Characterizing the temporal dynamics of human papillomavirus DNA detectability using short-interval sampling.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- HPV vaccination among seropositive, DNA negative cohorts: a systematic review & meta-analysis.Journal of gynecologic oncology · 2022Pooled it
- Immune Dysregulation and Viral Persistence in HPV-HIV Coinfection: Oncogenic and Clinical Implications.HIV/AIDS (Auckland, N.Z.) · 2026Review
- Longitudinal patterns of penile human papillomavirus detection among Ugandan men: A prospective sampling study.International journal of cancer · 2025Article
- Short-term repeat HPV testing for triaging HPV-positive women in cervical cancer screening.British journal of cancer · 2025Observational
- Accelerating HPV-related cancer elimination - a meeting report.BMC proceedings · 2025Article
- Article
- Cervical cancer: Challenges and prevention strategies: A narrative review.Health science reports · 2024Review
- "Easy women get it": pre-existing stigma associated with HPV and cervical cancer in a low-resource setting prior to implementation of an HPV screen-and-treat program.BMC public health · 2023Article
- Evidence of latent HPV infection in older Danish women with a previous history of cervical dysplasia.Acta obstetricia et gynecologica Scandinavica · 2022Article
- Incidence and clearance of oral and cervicogenital HPV infection: longitudinal analysis of the MHOC cohort study.BMJ open · 2022Article
- HPV and the Risk of HIV Acquisition in Women.Frontiers in cellular and infection microbiology · 2022Review
- Comparison between Urine and Cervical High-Risk HPV Tests for Japanese Women with ASC-US.Diagnostics (Basel, Switzerland) · 2021Article
- Screening for cervical cancer: Choices & dilemmas.The Indian journal of medical research · 2021Review
- Importance of Lifetime Sexual History on the Prevalence of Genital Human Papillomavirus (HPV) Among Unvaccinated Adults in the National Health and Nutrition Examination Surveys: Implications for Adult HPV Vaccination.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Rates of New Human Papillomavirus Detection and Loss of Detection in Middle-aged Women by Recent and Past Sexual Behavior.The Journal of infectious diseases · 2021Article
- Screening for the prevention and early detection of cervical cancer: protocol for systematic reviews to inform Canadian recommendations.Systematic reviews · 2021Article
- Association of Thiamine Intake with Human Papillomavirus (HPV) Infection in American Women: A Secondary Data Analysis Based on the National Health and Nutrition Examination Survey from 2003 to 2016.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- The Host-Microbe Interplay in Human Papillomavirus-Induced Carcinogenesis.Microorganisms · 2019Review
- Whole tissue cervical mapping of HPV infection: Molecular evidence for focal latent HPV infection in humans.Papillomavirus research (Amsterdam, Netherlands) · 2019Article
- Why Human Papillomavirus Acute Infections Matter.Viruses · 2017Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundVariable detection of human papillomavirus (HPV) DNA can result in misclassification of infection status, but the extent of misclassification has not been quantitatively evaluated.
methodsIn 2005-2007, 33 women of ages 22 to 53 years self-collected vaginal swabs twice per week for 16 consecutive weeks. Each of the 955 swabs collected was tested for 37 HPV types/subtypes. Assuming that a woman's underlying infection status did not change over the short study period, biases in prevalence estimates obtained from single versus multiple swabs were calculated. Using event history analysis methods, time to recurrent gain and loss of at least one HPV type was determined, separately. Baseline any-type and high risk-type HPV prevalence was 60.6% and 24.2%, respectively. Cumulative any-HPV and high-risk HPV prevalence over the 16-week period was 84.8% and 60.6%, separately.
resultsOverall, there were 319 events of detection and 313 events of loss of detection. Median times to a recurrent detection and loss of detection were 11 and seven days, respectively. Neither vaginal sex nor condom use during follow-up was associated with recurrent viral detection or loss of detection. Assuming the cumulative 16-week prevalence reflects the true prevalence of infection, the baseline any-HPV prevalence underestimated infection status by 24.2%, with a bootstrapped mean of 20.2% [95% confidence interval (CI), 8.9%-29.6%].
conclusionsThese findings suggest that a substantial proportion of HPV-infected women are misclassified as being uninfected when using a single-time DNA measurement. IMPACT: Short-term variation in detectable HPV DNA needs to be considered while interpreting the natural history of infections using single samples collected at long intervals.
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