ArticleInvestigative ophthalmology & visual science2013
Correlation between biomechanical responses of posterior sclera and IOP elevations during micro intraocular volume change.
Article in Investigative ophthalmology & visual science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Dietary inflammatory potential and glaucoma susceptibility: a nationally representative study from NHANES.International journal of ophthalmology · 2026Article
- Relationship Between Diurnal Variations of Episcleral Venous Pressure and Intraocular Pressure.Investigative ophthalmology & visual science · 2025Article
- Ocular Biomechanics and Glaucoma.Vision (Basel, Switzerland) · 2023Review
- Ocular pulse amplitude (OPA) in canineFrontiers in bioengineering and biotechnology · 2023Article
- Intraocular pressure effect of intravitreal conbercept injection for retinopathy of prematurity.Frontiers in pharmacology · 2023Article
- Ocular Pulse Amplitude Correlates With Ocular Rigidity at Native IOP Despite the Variability in Intraocular Pulse Volume With Each Heartbeat.Translational vision science & technology · 2022Article
- Biomechanics of the optic nerve head and sclera in canine glaucoma: A brief review.Veterinary ophthalmology · 2021Review
- Corneal pulsation and biomechanics during induced ocular pulse. An ex-vivo pilot study.PloS one · 2020Article
- Cyclic Pattern of Intraocular Pressure (IOP) and Transient IOP Fluctuations in Nonhuman Primates Measured with Continuous Wireless Telemetry.Current eye research · 2019Article
- Acute and chronic optic nerve head biomechanics and intraocular pressure changes in patients receiving multiple intravitreal injections of anti-VEGF.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019Article
- IOP, IOP Transient Impulse, Ocular Perfusion Pressure, and Mean Arterial Pressure Relationships in Nonhuman Primates Instrumented With Telemetry.Investigative ophthalmology & visual science · 2018Article
- Age-related changes in the response of retinal structure, function and blood flow to pressure modification in rats.Scientific reports · 2018Article
- Corneoscleral stiffening increases IOP spike magnitudes during rapid microvolumetric change in the eye.Experimental eye research · 2017Article
- Noninvasive measurement of wave speed of porcine cornea in ex vivo porcine eyes for various intraocular pressures.Ultrasonics · 2017Article
- Racioethnic Differences in Human Posterior Scleral and Optic Nerve Stump Deformation.Investigative ophthalmology & visual science · 2017Article
- Lamina cribrosa in glaucoma.Current opinion in ophthalmology · 2017Review
- Mapping 3D Strains with Ultrasound Speckle Tracking: Method Validation and Initial Results in Porcine Scleral Inflation.Annals of biomedical engineering · 2016Article
- Three-Dimensional Strains in Human Posterior Sclera Using Ultrasound Speckle Tracking.Journal of biomechanical engineering · 2016Article
- Influence of Age on Ocular Biomechanical Properties in a Canine Glaucoma Model with ADAMTS10 Mutation.PloS one · 2016Article
- High-Magnitude and/or High-Frequency Mechanical Strain Promotes Peripapillary Scleral Myofibroblast Differentiation.Investigative ophthalmology & visual science · 2015Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
purposeThis study tested the hypothesis that intraocular pressure (IOP) elevations, induced by controlled increase of intraocular volume, are correlated with the biomechanical responses of the posterior sclera.
methodsPorcine globes were tested within 48 hours postmortem. The first group of globes (n = 11) was infused with 15 μL of phosphate-buffered saline at three different rates to investigate rate-dependent IOP elevations. The second group (n = 16) was first infused at the fast rate and then underwent inflation tests to investigate the relationship between IOP elevations (ΔIOP) and scleral strains. The strains in the superotemporal region of the posterior sclera were measured by ultrasound speckle tracking. Linear regression was used to examine the association between ΔIOP due to micro-volumetric infusion and the scleral strains at a specific inflation pressure.
resultsThe average ΔIOP was 14.9 ± 4.3 mm Hg for the infusion of 15 μL in 1 second. The ΔIOP was greater for the faster infusion rates but highly correlated across different rates (P < 0.001). A significant negative association was found between the ΔIOP and the tangential strains in both the circumferential (R(2) = 0.54, P = 0.003) and meridian (R(2) = 0.53, P = 0.002) directions in the posterior sclera.
conclusionsThis study showed a substantial increase in IOP, with a large intersubject variance during micro-volumetric change. A stiffer response of the sclera was associated with larger IOP spikes, providing experimental evidence linking corneoscleral biomechanics to IOP fluctuation. In vivo measurement of corneoscleral biomechanics may help better predict the dynamic profile of IOP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.