ArticleAngewandte Chemie (International ed. in English)2014
Non-invasive and in situ characterization of the degradation of biomaterial scaffolds by volumetric photoacoustic microscopy.
Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Augmenting Tendon-to-Bone Repair with Functionally Graded Scaffolds.Advanced healthcare materials · 2021Review
- Capturing the Real-Time Hydrolytic Degradation of a Library of Biomedical Polymers by Combining Traditional Assessment and Electrochemical Sensors.Biomacromolecules · 2021Article
- Radiopaque scaffolds based on electrospun iodixanol/polycaprolactone fibrous composites.Materialia · 2020Article
- Photoacoustic Imaging in Tissue Engineering and Regenerative Medicine.Tissue engineering. Part B, Reviews · 2020Review
- A handheld microscope integrating photoacoustic microscopy and optical coherence tomography.Biomedical optics express · 2018Article
- Imaging Biomaterial-Tissue Interactions.Trends in biotechnology · 2018Review
- Inverse Opal Scaffolds and Their Biomedical Applications.Advanced materials (Deerfield Beach, Fla.) · 2017Review
- Novel enantiopure cyclopentadienyl Ti(IV) oximato compounds as potential anticancer agents.Journal of inorganic biochemistry · 2016Article
- Non-invasive and Non-destructive Characterization of Tissue Engineered Constructs Using Ultrasound Imaging Technologies: A Review.Annals of biomedical engineering · 2016Review
- Seeing Through the Surface: Non-invasive Characterization of Biomaterial-Tissue Interactions Using Photoacoustic Microscopy.Annals of biomedical engineering · 2016Review
- Pre-clinical characterization of tissue engineering constructs for bone and cartilage regeneration.Annals of biomedical engineering · 2015Review
- Imaging strategies for tissue engineering applications.Tissue engineering. Part B, Reviews · 2015Review
- Optical-resolution photoacoustic microscopy for volumetric and spectral analysis of histological and immunochemical samples.Angewandte Chemie (International ed. in English) · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Degradation is among the most important properties of biomaterial scaffolds, which are indispensable for regenerative medicine. The currently used method relies on the measurement of mass loss across different samples and cannot track the degradation of an individual scaffold in situ. Here we report, for the first time, the use of multiscale photoacoustic microscopy to non-invasively monitor the degradation of an individual scaffold. We could observe alterations to the morphology and structure of a scaffold at high spatial resolution and deep penetration, and more significantly, quantify the degradation of an individual scaffold as a function of time, both in vitro and in vivo. In addition, the remodeling of vasculature inside a scaffold can be visualized simultaneously using a dual-wavelength scanning mode in a label-free manner. This optoacoustic method can be used to monitor the degradation of individual scaffolds, offering a new approach to non-invasively analyze and quantify biomaterial-tissue interactions in conjunction with the assessment of in vivo vascular parameters.
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Registered trials
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