ArticleBioEssays : news and reviews in molecular, cellular and developmental biology2013
Death by transposition - the enemy within?
Article in BioEssays : news and reviews in molecular, cellular and developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum).Advanced biology · 2025Article
- Reactivation of retrotransposable elements is associated with environmental stress and ageing.Nature reviews. Genetics · 2025Review
- LINE-1 retrotransposon activation drives age-associated inflammationContemporary oncology (Poznan, Poland) · 2025Review
- Dysregulation of endogenous retroviruses triggers aging and senescence.Nature aging · 2024Article
- Navigating the brain and aging: exploring the impact of transposable elements from health to disease.Frontiers in cell and developmental biology · 2024Review
- The role of transposable elements in aging and cancer.Biogerontology · 2023Review
- The Role of Mitotic Slippage in Creating a "Female Pregnancy-like System" in a Single Polyploid Giant Cancer Cell.International journal of molecular sciences · 2023Article
- Article
- A retrotransposon storm marks clinical phenoconversion to late-onset Alzheimer's disease.GeroScience · 2022Article
- Somatic Mobilization: High Somatic Insertion Rate ofInsects · 2022Article
- Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models.Frontiers in aging · 2022Review
- Healthy Aging Interventions Reduce Repetitive Element Transcripts.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Review
- Transposable Element Landscape in Drosophila Populations Selected for Longevity.Genome biology and evolution · 2021Article
- Review
- Type I interferons and related pathways in cell senescence.Aging cell · 2020Review
- Repetitive elements as a transcriptomic marker of aging: Evidence in multiple datasets and models.Aging cell · 2020Article
- Demethylation and derepression of genomic retroelements in the skeletal muscles of aged mice.Aging cell · 2019Article
- New Insights into Chronological Mobility of Retrotransposons In Vivo.Oxidative medicine and cellular longevity · 2019Article
- Cellular Metabolism and Aging.Progress in molecular biology and translational science · 2018Review
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9 authors.
Funding
Abstract
Here we present and develop the hypothesis that the derepression of endogenous retrotransposable elements (RTEs) - "genomic parasites" - is an important and hitherto under-unexplored molecular aging process that can potentially occur in most tissues. We further envision that the activation and continued presence of retrotransposition contribute to age-associated tissue degeneration and pathology. Chromatin is a complex and dynamic structure that needs to be maintained in a functional state throughout our lifetime. Studies of diverse species have revealed that chromatin undergoes extensive rearrangements during aging. Cellular senescence, an important component of mammalian aging, has recently been associated with decreased heterochromatinization of normally silenced regions of the genome. These changes lead to the expression of RTEs, culminating in their transposition. RTEs are common in all kingdoms of life, and comprise close to 50% of mammalian genomes. They are tightly controlled, as their activity is highly destabilizing and mutagenic to their resident genomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.