Evidence map›Paper›PMID 24129909›Full record

ArticleJournal of neurovirology2013

Feasibility and potential role of ferumoxytol-enhanced neuroimaging in HIV-associated neurocognitive disorder.

Beau K Nakamoto, Cecilia M Shikuma, Debra Ogata-Arakaki, Tracie Umaki, Edward A Neuwelt, Bruce T Shiramizu, Dominic C Chow, Nisha I Parikh, Kalpana J Kallianpur, Bronwyn E Hamilton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurovirology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Interactions between ageing and NeuroAIDS.Current opinion in HIV and AIDS · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Beau K NakamotoHawaii Center for AIDS, University of Hawaii, Honolulu, HI, USA, beau_nakamoto@yahoo.com.
Cecilia M Shikuma
Debra Ogata-Arakaki
Tracie Umaki
Edward A Neuwelt
Bruce T Shiramizu
Dominic C Chow
Nisha I Parikh
Kalpana J Kallianpur
Bronwyn E Hamilton

Funding

RESEARCH DESIGN AND BIOSTATISTICS COREU54MD007584 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI MOKUAU, NOREEN, SHIRAMIZU, BRUCE T · 2012 to 2018
$21.1M
WILLINGNESS OF PRIMARY CARE PHYSICIANS TO ADOPT HANDHELD COMPUTINGP20RR011091 · NCRR · UNIVERSITY OF HAWAII AT MANOA · PI ERDEM, GULIZ · 1995 to 2009
$16.5M
PBI Manufacture CoreU19MH081835 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HADLOCK, KENNETH · 2007 to 2011
$8.9M
Two Compartment Models to Improve Brain Tumor TherapyR01CA137488 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI NEUWELT, EDWARD A. · 2008 to 2019
$7.3M
University of Hawaii NeuroAIDS SNRPU54NS043049 · NINDS · UNIVERSITY OF HAWAII AT MANOA · PI SHIKUMA, CECILIA M · 2001 to 2005
$7.0M
Role of Oxidative Stress and Inflammation in HIV Cardiovascular RiskR01HL095135 · NHLBI · UNIVERSITY OF HAWAII AT MANOA · PI SHIKUMA, CECILIA M. · 2008 to 2012
$4.5M
Opening of the blood-brain barrier to antitumor agentsR01NS044687 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI NEUWELT, EDWARD A. · 2010 to 2014
$3.1M
Nanoparticle MR Imaging of BBB Inflammation at High Tesla in CNS TumorsR01NS053468 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI NEUWELT, EDWARD A. · 2007 to 2011
$2.8M
HIV-1 Proviral DNA and Monocyte Phenotype in Relation to Neurocognitive FunctionR01NS053345 · NINDS · UNIVERSITY OF HAWAII AT MANOA · PI SHIRAMIZU, BRUCE T · 2006 to 2010
$1.2M
Cardiovascular autonomic function in HIV virologic failureK23HL088981 · NHLBI · UNIVERSITY OF HAWAII AT MANOA · PI CHOW, DOMINIC C · 2008 to 2011
$580k
NCI NIH HHS R01 CA137488NCRR NIH HHS P20 RR011091NCRR NIH HHS P20RR011091NHLBI NIH HHS K23 HL088981NHLBI NIH HHS R01 HL095135NHLBI NIH HHS R01HL095135NIMHD NIH HHS U54 MD007584NIMHD NIH HHS U54MD007584NIMH NIH HHS U19 MH081835NIMH NIH HHS U19MH081835NINDS NIH HHS R01 NS044687NINDS NIH HHS R01 NS053345NINDS NIH HHS R01NS053345NINDS NIH HHS R01 NS053468NINDS NIH HHS U54 NS043049NINDS NIH HHS U54NS43049
6 · The paper itself

Abstract

We assessed ferumoxytol-enhanced brain MRI to identify monocyte/macrophage accumulation in HIV-associated neurocognitive disorder (HAND). Four HIV-infected subjects with undetectable HIV RNA levels on antiretroviral therapy, HIV DNA level in CD14+ cells ≥10 copies/10(6) cells, and cognitive impairment underwent ferumoxytol-enhanced brain MRI. On post-ferumoxytol susceptibility-weighted images, all HIV-infected subjects demonstrated a diffuse "tram track" appearance in the perivascular regions of cortical and deep white matter vessels suggesting ferumoxytol uptake in monocytes/macrophages. This finding was not present in an HIV-seronegative control. While ferumoxytol may have potential as an imaging biomarker for monocyte/macrophage accumulation in patients with HAND, future study is needed.

Indexed as

Ferrosoferric OxideHIV-1AgedAnti-HIV AgentsCase-Control StudiesCell MovementCerebral CortexCognition DisordersFeasibility StudiesHIV InfectionsHumansLipopolysaccharide ReceptorsMacrophagesMagnetic Resonance ImagingMaleMiddle AgedAnti-HIV AgentsFerrosoferric OxideLipopolysaccharide ReceptorsRNA, Viral

Identifiers

PMID24129909
PMCPMC3947641

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.