ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2013
Prognostic impact of lymph node retrieval and ratio in gastric cancer: a U.S. single center experience.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- A nomogram integrating multidimensional lymph node indicators with clinicopathological factors predicts overall survival in non-metastatic gastric cancer patients after radical gastrectomy.Translational cancer research · 2026Article
- Evaluation of lymph node ratios and log odds of positive nodes as prognostic indicators in primary organ malignancy.Medical journal, Armed Forces India · 2025Article
- Lymph Node Yield and Lymph Node Ratio for Prognosis of Long-Term Survival in Gastric Carcinoma.Cancers · 2025Article
- Prognostic performance of examined lymph nodes, lymph node ratio, and positive lymph nodes in gastric cancer: a competing risk model study.Frontiers in endocrinology · 2025Article
- Metastatic lymph node ratio and Lauren classification are independent prognostic markers for survival rates of patients with gastric cancer.Oncology letters · 2018Article
- Comparison of different lymph node staging systems in prognosis of gastric cancer: a bi-institutional study from Hungary.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2017Article
- N staging system: tumor-node-metastasis and future perspectives.Translational gastroenterology and hepatology · 2017Review
- Does a Higher Cutoff Value of Lymph Node Retrieval Substantially Improve Survival in Patients With Advanced Gastric Cancer?-Time to Embrace a New Digit.The oncologist · 2017Article
- Clinicopathologic implication of meticulous pathologic examination of regional lymph nodes in gastric cancer patients.PloS one · 2017Article
- The Ratio-Based N Staging System Can More Accurately Reflect the Prognosis of T4 Gastric Cancer Patients with D2 Lymphadenectomy Compared with the 7th American Joint Committee on Cancer/Union for International Cancer Control Staging System.Journal of gastric cancer · 2016Article
- Seventh tumor-node-metastasis staging of gastric cancer: Five-year follow-up.World journal of gastroenterology · 2016Review
- Positive Lymph Node Ratio as an Indicator of Prognosis and Local Tumor Clearance in N3 Gastric Cancer.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016Article
- Article
- Prognostic value of three different lymph node staging systems in the survival of patients with gastric cancer following D2 lymphadenectomy.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- A clinical prognostic scoring system for resectable gastric cancer to predict survival and benefit from paclitaxel- or oxaliplatin-based adjuvant chemotherapy.Drug design, development and therapy · 2016Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIncreased lymph node (LN) retrieval for gastric cancer has been associated with improved overall survival (OS). This study examines the impact of number of examined LN (eLN) and lymph node ratio.
methodsPatients referred for surgical care of gastric cancer were stratified by number of eLN, positive LNs (LN+), and lymph node ratio (LN+/eLN). Clinicopathologic factors were compared; OS and disease-free survival (DFS) were the primary endpoints.
resultsFrom 1997 to 2012, 222 patients, median age 67 (range, 17-92) years, were analyzed. Of 220 (99 %) explored, 164 (74 %) underwent resection. Median OS was 22 (range, 0.3-140) months. Perineural and lymphovascular invasion and poor differentiation adversely affected OS, p < 0.05. A median 14 eLN (range, 0-45), with median 1 LN+ (range, 0-31), was observed. There were no OS or DFS differences when comparing the eLN groups. Both OS and DFS were impacted by LN+. Lymph node ratio demonstrated worse median OS with increasing ratio: 49 months (0) to 37 months (0.01-0.2), 27 months (0.21-0.5), and 12 months (>0.5), p < 0.0001. DFS was similar: 35 months (0), decreasing to 22 months (0.01-0.2), 13 months (0.21-0.5), and 7 months (>0.5), p < 0.0001.
conclusionNumber of eLN did not impact survival, while LN+ adversely affected survival. Lymph node ratio may predict prognosis better than number of eLN or LN+ in gastric cancer.
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