ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2015
Joint models for predicting transplant-related mortality from quality of life data.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Joint modelling on clinical trials in clinical journals: a systematic review.BMC medical research methodology · 2026Pooled it
- Joint models for longitudinal and time-to-event data: a review of reporting quality with a view to meta-analysis.BMC medical research methodology · 2016Pooled it
- Flexible modeling of longitudinal health-related quality of life data accounting for informative dropout in a cancer clinical trial.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Trial
- Significant improvement of child physical and emotional functioning after familial haploidentical stem cell transplant.Bone marrow transplantation · 2022Trial
- Article
- Association of eGFR and mortality with use of a joint model: results of a nationwide study in Iceland.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Article
- Health-related quality of life predicts length of hospital stay and survival rates for pediatric patients receiving allogeneic hematopoietic cell transplantation.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Article
- Exercise before, during, and after Hospitalization for Allogeneic Hematological Stem Cell Transplant: A Feasibility Randomized Controlled Trial.Journal of clinical medicine · 2020Article
- An introduction to joint models-applications in nephrology.Clinical kidney journal · 2020Review
- Everyday life following hematopoietic stem cell transplantation: decline in physical symptoms within the first month and change-related predictors.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018Article
- Introduction to special section: quantitative methods.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015Article
- Assessing model fit in joint models of longitudinal and survival data with applications to cancer clinical trials.Statistics in medicine · 2014Article
- Predicting Health Care Utilization for Children With Respiratory Insufficiency Using Parent-Proxy Ratings of Children's Health-Related Quality of Life.Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & PractitionersArticle
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3 authors.
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Abstract
purposeTo test whether longitudinally measured health-related quality of life (HRQL) predicts transplant-related mortality (TRM) in pediatric hematopoietic stem cell transplant (HSCT).
methodsThe predictors of interest were emotional functioning, physical functioning, role functioning, and global HRQL, as rated by the parent about the child up to 6 times over 12 months of follow-up and measured by the Child Health Ratings Inventories. We used joint models, specifically shared parameter models, with time to TRM as the outcome of interest and other causes of mortality as a competing risk, via the JM software package in R. Choosing shared parameter models instead of standard survival models, such as Cox models with time-dependent covariates, enabled us to address measurement error in the HRQL trajectories and appropriately handle missing data. The nonlinear trajectories for each HRQL domain were modeled by random spline functions. The survival submodels were adjusted for baseline patient, family, and transplant characteristics.
resultsHazard ratios per one-half standard deviation difference in emotional, physical, and role functioning, and global HRQL were 0.61 (95 % CI 0.46-0.81; p < 0.001), 0.70 (0.51-0.96; p = 0.03), 0.54 (0.34-0.85; p = 0.007), and 0.57 (0.41-0.79; p < 0.001), respectively.
conclusionsHRQL trajectories were predictive of TRM in pediatric HSCT, even after adjusting the survival outcome for baseline characteristics.
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