SynthesisQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2014
Meta-analysis shows clinically relevant and long-lasting deterioration in health-related quality of life after esophageal cancer surgery.
Synthesis in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05802459 (Prospective Evaluation of the Functional Status of Jejunoplasty and Coloplasty in Patients Undergoing Complex Esophageal Reconstruction and Its Impact on Quality of Life), which is not on this map. Cited by 35 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Evaluation of the Functional Status of Jejunoplasty and Coloplasty in Patients Undergoing Complex Esophageal Reconstruction and Its Impact on Quality of Life (CEREC)
Who cites it
35 citing papers in PubMed, 6 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Health-related quality of life in esophageal cancer: a state-of-the-art review of patient-reported outcomes and an evidence and gap map.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2025Pooled it
- Self-care advice for patients after surgery for oesophageal cancer - a mixed-methods systematic review.Journal of cancer survivorship : research and practice · 2025Pooled it
- Exercise-based dysphagia rehabilitation for adults with oesophageal cancer: a systematic review.BMC cancer · 2022Pooled it
- The change of health-related quality of life after minimally invasive esophagectomy for esophageal cancer: a meta-analysis.World journal of surgical oncology · 2018Pooled it
- Prediction models for patients with esophageal or gastric cancer: A systematic review and meta-analysis.PloS one · 2018Pooled it
- Minimally invasive oesophagectomy versus open esophagectomy for resectable esophageal cancer: a meta-analysis.World journal of surgical oncology · 2016Pooled it
- Symptomatic reactive hypoglycemia is highly prevalent post-esophagectomy.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2026Article
- Position and outcomes of Minimally Invasive transCervical Esophagectomy (MICE) in treatment of esophageal cancer.Journal of thoracic disease · 2026Article
- Symptom clusters in oesophageal cancer patients during varying phases of postoperative chemotherapy: a scoping review.BMJ open · 2026Article
- Effect of structured nursing care on treatment tolerance and quality of life in patients with esophageal cancer undergoing radiotherapy: a retrospective cohort study.Frontiers in oncology · 2026Article
- Investigating Nutrition and Supportive Care Needs in Esophageal and Gastric Cancer Survivors: A Cross-Sectional Survey.Healthcare (Basel, Switzerland) · 2025Article
- Postoperative complications and health-related quality of life after oesophageal cancer surgery: a national, population-based cohort study.Acta oncologica (Stockholm, Sweden) · 2024Article
- Longitudinal patient-reported outcomes after minimally invasive McKeown esophagectomy for patients with esophageal squamous cell carcinoma.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Unveiling Therapeutic Targets for Esophageal Cancer: A Comprehensive Review.Current oncology (Toronto, Ont.) · 2023Review
- Quality of Life in Patients Undergoing Surgery for Upper GI Malignancies.Life (Basel, Switzerland) · 2023Review
- Symptoms, problems and quality of life in patients newly diagnosed with oesophageal and gastric cancer - a comparative study of treatment strategy.BMC cancer · 2022Article
- Risk factors of lymph node metastasis or lymphovascular invasion for superficial esophageal squamous cell carcinoma: A practical and effective predictive nomogram based on a cancer hospital data.Frontiers in medicine · 2022Article
- A novel web-based dynamic nomogram for recurrent laryngeal nerve lymph node metastasis in esophageal squamous cell carcinoma.Frontiers in surgery · 2022Article
- Establishment of a Preoperative Laboratory Panel to identify Lymph Node Metastasis in Superficial Esophageal Cancer.Journal of Cancer · 2022Article
- Severe reflux, sleep disturbances, and health-related quality of life after esophageal cancer surgery.Journal of cancer survivorship : research and practice · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
purposeThe purpose of the study is to (1) estimate the direction, clinical relevance, and duration of health-related quality of life (HRQL) change in the first year following esophageal cancer surgery and (2) to assess the robustness of the estimates by subgroup and sensitivity analyses, and an exploration of publication bias.
methodsA systematic literature search in MEDLINE, EMBASE, CINAHL, PsychINFO, and CENTRAL to identify randomized and non-randomized studies was performed. We compared the baseline HRQL data with 3-, 6-, 9-, or 12-month follow-ups to estimate the magnitude and duration of HRQL change. These estimates were then classified as trivial, small, medium, or large. Primary outcomes were role functioning, eating, and fatigue. Secondary outcomes were physical and social functioning, dysphagia, pain, and coughing problems. We conducted subgroup analysis for open surgery, open surgery preceded by neo-adjuvant therapy, and minimally invasive surgery. Sensitivity analyses assessed the influence of study design, transformation/imputation of the data, and HRQL questionnaire used.
resultsWe included data from 15 studies to estimate the change in 28 HRQL outcomes after esophageal cancer surgery. The main analysis showed that patients' social functioning deteriorated. Symptoms of fatigue, pain, and coughing problems increased. These changes lasted for 9-12 months, although some symptoms persisted beyond the first year after surgery. For many other HRQL outcomes, estimates were only robust after subgroup or sensitivity analyses (e.g., role and physical functioning), or remained too heterogeneous to interpret (e.g., eating and dysphagia).
conclusionsPatients will experience a clinically relevant and long-lasting deterioration in HRQL after esophageal cancer surgery. However, for many HRQL outcomes, more and better quality evidence is needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.