ArticleNature communications2013
Arabidopsis WAT1 is a vacuolar auxin transport facilitator required for auxin homoeostasis.
Article in Nature communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers.
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156 citing papers in PubMed, 304 citations in OpenAlex.
- Genome-Wide Identification and Characterization of the UMAMIT Gene Family inInternational journal of molecular sciences · 2026Article
- Metabolism meets transport: a new perspective on auxin homeostasis at subcellular level.Planta · 2026Review
- Genome-Wide Identification of the Soybean UMAMIT Family and Functional Analysis ofInternational journal of molecular sciences · 2026Article
- Proteomic analysis of rose apple reveals defense proteins activated during Lasiodiplodia theobromae infection.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Rhizophagus irregularis modulates neighbour-primed defences in Medicago truncatula against foliar pathogens via common mycelial network-mediated inter-plant signals.Communications biology · 2026Article
- Differential transcriptomic landscapes of olive cultivars facing Xylella fastidiosa infection.BMC plant biology · 2026Article
- ABT Promotes Adventitious Root Formation in Mulberry Cuttings by Coordinating Hormonal Homeostasis and Defense Priming.Current issues in molecular biology · 2026Article
- Tailored for swift recognition: A structural perspective on secondary active plant hormone transporters.The Plant journal : for cell and molecular biology · 2026Review
- Unexpected Dual Function of Plant YUCCA Enzymes Links Chlorophyll Catabolism to Auxin Homeostasis.Angewandte Chemie (International ed. in English) · 2026Article
- The Arabidopsis neutral amino acid transporter UmamiT20 confers Botrytis cinerea susceptibility.Journal of experimental botany · 2026Article
- Hormone-centric multi-omics atlas of flower and early fruit development in tomato.Plant communications · 2026Article
- Pretreatment with Silver Thiosulfate Increases the Auxin-Inductive Effect for Rooting Mature Chestnut Shoots.Plants (Basel, Switzerland) · 2025Article
- Chromosome-scale assemblies of flowering dogwood cultivars enable identification of candidate genes regulating anthocyanin biosynthesis in leaves and bracts.BMC plant biology · 2025Article
- Overexpression of Tempranillo-Like Proteins Promotes Dormancy Release in Poplar.Plant, cell & environment · 2025Article
- Integrated Transcriptomic and Biochemical Analyses Reveal the Root Development-Promoting Mechanism ofPlants (Basel, Switzerland) · 2025Article
- Characterization of Grain Structure Using Micro-CT and Identification of Related Candidate Genes by QTL Mapping in Foxtail Millet.Plants (Basel, Switzerland) · 2025Article
- AgroDrug Conjugates for Sustainable Crop Protection: Molecular Architectures, Mechanisms, and Critical Perspectives.Topics in current chemistry (Cham) · 2025Review
- The Enhancement of Fungal Disease Resistance in Major Staple Crops Using CRISPR-Cas Technology.Genes · 2025Review
- Single-nucleus transcriptomics revealed auxin-driven mechanisms of wood plasticity to enhance severe drought tolerance in poplar.Genome biology · 2025Article
- Mechanisms of auxin action in plant growth and development.Nature reviews. Molecular cell biology · 2025Review
96 more citing papers are in PubMed but not listed here.
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Authors and funding
18 authors at 9 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plant hormone auxin (indole-3-acetic acid, IAA) has a crucial role in plant development. Its spatiotemporal distribution is controlled by a combination of biosynthetic, metabolic and transport mechanisms. Four families of auxin transporters have been identified that mediate transport across the plasma or endoplasmic reticulum membrane. Here we report the discovery and the functional characterization of the first vacuolar auxin transporter. We demonstrate that WALLS ARE THIN1 (WAT1), a plant-specific protein that dictates secondary cell wall thickness of wood fibres, facilitates auxin export from isolated Arabidopsis vacuoles in yeast and in Xenopus oocytes. We unambiguously identify IAA and related metabolites in isolated Arabidopsis vacuoles, suggesting a key role for the vacuole in intracellular auxin homoeostasis. Moreover, local auxin application onto wat1 mutant stems restores fibre cell wall thickness. Our study provides new insight into the complexity of auxin transport in plants and a means to dissect auxin function during fibre differentiation.
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