ArticleHeredity2014
The genetic basis and experimental evolution of inbreeding depression in Caenorhabditis elegans.
Article in Heredity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Origins of Self-Fertility in ThreeBiology · 2026Review
- Not just mutations: inbreeding depression persists without genetic variation.Evolution letters · 2026Article
- Variation in mutational (co)variances.G3 (Bethesda, Md.) · 2023Article
- Efficient production of CRISPR/Cas9 gene knockouts in the male/female nematodemicroPublication biology · 2023Article
- Gene-level quantitative trait mapping in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2021Article
- Population Selection and Sequencing ofG3 (Bethesda, Md.) · 2019Article
- Partial Selfing Can Reduce Genetic Loads While Maintaining Diversity During Experimental Evolution.G3 (Bethesda, Md.) · 2019Article
- SNP variable selection by generalized graph domination.PloS one · 2019Article
- Article
- Experimental Evolution withGenetics · 2017Review
- Variation in rates of spontaneous male production within the nematode species Pristionchus pacificus supports an adaptive role for males and outcrossing.BMC evolutionary biology · 2017Article
- C. elegans outside the Petri dish.eLife · 2015Review
- Reproductive assurance drives transitions to self-fertilization in experimental Caenorhabditis elegans.BMC biology · 2014Article
- Hermaphrodite life history and the maintenance of partial selfing in experimental populations of Caenorhabditis elegans.BMC evolutionary biology · 2014Article
- The role of hermaphrodites in the experimental evolution of increased outcrossing rates in Caenorhabditis elegans.BMC evolutionary biology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Determining the genetic basis of inbreeding depression is important for understanding the role of selection in the evolution of mixed breeding systems. Here, we investigate how androdioecy (a breeding system characterized by partial selfing and outcrossing) and dioecy (characterized by obligatory outcrossing) influence the experimental evolution of inbreeding depression in Caenorhabditis elegans. We derived inbred lines from ancestral and evolved populations and found that the dioecious lineages underwent more extinction than androdioecious lineages. For both breeding systems, however, there was selection during inbreeding because the diversity patterns of 337 single-nucleotide polymorphisms (SNPs) among surviving inbred lines deviated from neutral expectations. In parallel, we also followed the evolution of embryo to adult viability, which revealed similar starting levels of inbreeding depression in both breeding systems, but also outbreeding depression. Under androdioecy, diversity at a neutral subset of 134 SNPs correlated well with the viability trajectories, showing that the population genetic structure imposed by partial selfing affected the opportunity for different forms of selection. Our findings suggest that the interplay between the disruptions of coevolved sets of loci by outcrossing, the efficient purging of deleterious recessive alleles with selfing and overdominant selection with outcrossing can help explain mixed breeding systems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.