ReviewClinical and experimental nephrology2014
Genetic associations in diabetic nephropathy.
Review in Clinical and experimental nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Association between PAI-1 4G/5G polymorphism and diabetic nephropathy: a meta-analysis in the Chinese population.International urology and nephrology · 2016Pooled it
- Common genetic variants in dyslipidemia, inflammation, and angiogenesis pathways associated with diabetic nephropathy in Tunisians.Endocrine · 2026Article
- Serpin Family B Member 2 Polymorphisms in Patients with Diabetic Kidney Disease: An Association Study.International journal of molecular sciences · 2024Article
- Diabetic kidney disease in pediatric patients: A current review.World journal of diabetes · 2022Review
- Administration of mesenchymal stem cells in diabetic kidney disease: mechanisms, signaling pathways, and preclinical evidence.Molecular and cellular biochemistry · 2022Review
- Estimation of Fluoride and Sirtuin1 in Patients with Diabetic Nephropathy in Kolar District of Karnataka, India.Journal of laboratory physicians · 2022Article
- MicroRNA-499a (rs3746444A/G) gene variant and susceptibility to type 2 diabetes-associated end-stage renal disease.Experimental and therapeutic medicine · 2022Article
- IL10 haplotypes are associated with diabetic nephropathy susceptibility in patients from western Mexico.Journal of clinical laboratory analysis · 2019Article
- The Role of ERRFI1+808T/G Polymorphism in Diabetic Nephropathy.International journal of molecular and cellular medicine · 2019Article
- The real culprit behind diabetic nephropathy: impaired renal autoregulation?Physiological reports · 2017Article
- The Short-Term Remission of Diabetic Nephropathy After Roux-en-Y Gastric Bypass in Chinese Patients of T2DM with Obesity.Obesity surgery · 2015Article
- The Prevalence and Management of Diabetic Nephropathy in Asia.Kidney diseases (Basel, Switzerland) · 2015Review
- [Diabetic nephropathy: current diagnostics and treatment].Der Internist · 2015Article
- Diabetic nephropathy - complications and treatment.International journal of nephrology and renovascular disease · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic nephropathy is a complex disease, caused by both environmental and genetic factors. As in most complex diseases, genetic association studies in diabetic nephropathy showed inconsistent results. In retrospect, studies with small sample sizes, given what are now known to be small odds ratios, were partially responsible for this poor replication record. Furthermore, the low prior probability in complex genetics and multiple testing played a role. Results become more consistent when one only considers those that were replicated. In a large meta-analysis study including only replicated associated genetic variants, 24 genetic variants in 16 genes were found to be associated with diabetic nephropathy. These genetic variants may provide novel biological insight. In particular, rare variants with a large effect found by hypothesis-free approaches (genome-wide association scans, next-generation sequencing) may open new avenues of discovery.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.