Evidence map›Paper›PMID 24129434›Full record

ArticleEuropean journal of human genetics : EJHG2014

Life insurance: genomic stratification and risk classification.

Yann Joly, Hilary Burton, Bartha Maria Knoppers, Ida Ngueng Feze, Tom Dent, Nora Pashayan, Susmita Chowdhury, William Foulkes, Alison Hall, Pavel Hamet and 4 more

Abstract readLetter
In one paragraph

Article in European journal of human genetics : EJHG, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. How are genetic test results being used by Australian life insurers?European journal of human genetics : EJHG · 2018
    Article
  7. Hypertension genomics and cardiovascular prevention.Annals of translational medicine · 2018
    Review
  8. Article
  9. Article
  10. Article
  11. Genetic discrimination legislation in Canada: moving from rhetoric to real debate.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2016
    Article
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yann JolyCenter of Genomics and Policy, McGill University, Montreal, QC, Canada.
Hilary BurtonPHG Foundation, Cambridge, UK.
Bartha Maria KnoppersCenter of Genomics and Policy, McGill University, Montreal, QC, Canada.
Ida Ngueng FezeCenter of Genomics and Policy, McGill University, Montreal, QC, Canada.
Tom DentPHG Foundation, Cambridge, UK.
Nora PashayanUniversity College London, London, UK.
Susmita ChowdhuryPHG Foundation, Cambridge, UK.
William FoulkesCenter of Genomics and Policy, McGill University, Montreal, QC, Canada.
Alison HallPHG Foundation, Cambridge, UK.
Pavel HametCentre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.
Nick KirwanAssociation of British Insurers, London, UK.
Angus MacdonaldHeriot-Watt University, Edinburgh, UK.
Jacques SimardLaval University, Quebec City, QC, Canada.
Ine Van HoyweghenMaastricht University, Maastricht, The Netherlands.

Funding

Cancer Research UK 13065CIHR 87521
6 · The paper itself

Abstract

With the development and increasing accessibility of new genomic tools such as next-generation sequencing, genome-wide association studies, and genomic stratification models, the debate on genetic discrimination in the context of life insurance became even more complex, requiring a review of current practices and the exploration of new scenarios. In this perspective, a multidisciplinary group of international experts representing different interests revisited the genetics and life insurance debate during a 2-day symposium 'Life insurance: breast cancer research and genetic risk prediction seminar' held in Quebec City, Canada on 24 and 25 September 2012. Having reviewed the current legal, social, and ethical issues on the use of genomic information in the context of life insurance, the Expert Group identified four main questions: (1) Have recent developments in genomics and related sciences changed the contours of the genetics and life insurance debate? (2) Are genomic results obtained in a research context relevant for life insurance underwriting? (3) Should predictive risk assessment and risk stratification models based on genomic data also be used for life insurance underwriting? (4) What positive actions could stakeholders in the debate take to alleviate concerns over the use of genomic information by life insurance underwriters? This paper presents a summary of the discussions and the specific action items recommended by the Expert Group.

Indexed as

Genetic TestingInsurance, LifeRisk AssessmentCanadaGenome-Wide Association StudyGenomicsHumans

Identifiers

PMID24129434
PMCPMC3992580

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.