ArticleEuropean journal of human genetics : EJHG2014
Genome-wide patterns of identity-by-descent sharing in the French Canadian founder population.
Article in European journal of human genetics : EJHG, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- The genetic legacy of the 17th-century colonial capital of St. Mary's City.Current biology : CB · 2026Article
- Fine-scale structure of a whole regional population through genetics and genealogies.Nature communications · 2026Article
- A multi-ancestry genetic reference for the Quebec population.Nature communications · 2026Article
- Using the ancestral recombination graph to study the history of rare variants in founder populations.American journal of human genetics · 2025Article
- Rare diseases load through the study of a regional population.PLoS genetics · 2025Article
- Fine-scale genetic structure and rare variant frequencies.PloS one · 2024Article
- Deciphering the genetic structure of the Quebec founder population using genealogies.European journal of human genetics : EJHG · 2024Article
- Leveraging health systems data to characterize a large effect variant conferring risk for liver disease in Puerto Ricans.American journal of human genetics · 2021Article
- Review
- Correspondence Between Genomic- and Genealogical/Coalescent-Based Inference of Homozygosity by Descent in Large French-Canadian Genealogies.Frontiers in genetics · 2021Article
- Estimating Lactase Nonpersistence Distributions in the Multi-Ethnic Canadian Demographic: A Population-Based Study.Journal of the Canadian Association of Gastroenterology · 2020Article
- Founder BRCA1/BRCA2/PALB2 pathogenic variants in French-Canadian breast cancer cases and controls.Scientific reports · 2020Article
- Ventricular Arrhythmia in Septal and Apical Hypertrophic Cardiomyopathy: The French-Canadian Experience.Frontiers in cardiovascular medicine · 2020Article
- Exploring rare and low-frequency variants in the Saguenay-Lac-Saint-Jean population identified genes associated with asthma and allergy traits.European journal of human genetics : EJHG · 2019Article
- Inferring Transmission Histories of Rare Alleles in Population-Scale Genealogies.American journal of human genetics · 2018Article
- Haplotype Sharing Provides Insights into Fine-Scale Population History and Disease in Finland.American journal of human genetics · 2018Article
- Clustering of 770,000 genomes reveals post-colonial population structure of North America.Nature communications · 2017Article
- Whole-genome sequencing in French Canadians from Quebec.Human genetics · 2016Article
- Rapidly Registering Identity-by-Descent Across Ancestral Recombination Graphs.Journal of computational biology : a journal of computational molecular cell biology · 2016Article
- GENLIB: an R package for the analysis of genealogical data.BMC bioinformatics · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
In genetics the ability to accurately describe the familial relationships among a group of individuals can be very useful. Recent statistical tools succeeded in assessing the degree of relatedness up to 6-7 generations with good power using dense genome-wide single-nucleotide polymorphism data to estimate the extent of identity-by-descent (IBD) sharing. It is therefore important to describe genome-wide patterns of IBD sharing for more remote and complex relatedness between individuals, such as that observed in a founder population like Quebec, Canada. Taking advantage of the extended genealogical records of the French Canadian founder population, we first compared different tools to identify regions of IBD in order to best describe genome-wide IBD sharing and its correlation with genealogical characteristics. Results showed that the extent of IBD sharing identified with FastIBD correlates best with relatedness measured using genealogical data. Total length of IBD sharing explained 85% of the genealogical kinship's variance. In addition, we observed significantly higher sharing in pairs of individuals with at least one inbred ancestor compared with those without any. Furthermore, patterns of IBD sharing and average sharing were different across regional populations, consistent with the settlement history of Quebec. Our results suggest that, as expected, the complex relatedness present in founder populations is reflected in patterns of IBD sharing. Using these patterns, it is thus possible to gain insight on the types of distant relationships in a sample from a founder population like Quebec.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.