ArticleBritish journal of cancer2013
Validation of the Children's International Mucositis Evaluation Scale (ChIMES) in paediatric cancer and SCT.
Article in British journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06623305 (Photobiomodulation Therapy for the Prevention of Mucositis in Pediatric Oncology Patients), which is not on this map. Cited by 17 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Photobiomodulation Therapy for the Prevention of Mucositis in Pediatric Oncology Patients
Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Prevention and the treatment of oral mucositis: the efficacy of sodium bicarbonate vs other agents: a systematic review.BMC oral health · 2023Pooled it
- The impact of oral health education on the incidence and severity of oral mucositis in pediatric cancer patients: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Pooled it
- Child and adolescent self-report symptom measurement in pediatric oncology research: a systematic literature review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018Pooled it
- Self-report of symptoms in children with cancer younger than 8 years of age: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Pooled it
- Oral microbiome diversity and composition before and after chemotherapy treatment in pediatric oncology patients.BMC oral health · 2025Trial
- Impact of oral mucositis treated by photobiomodulation protocol on the quality of life of pediatric oncology patients with acute lymphoblastic leukemia.Lasers in medical science · 2026Article
- Pediatric Palliative Care: Insights into Assessment Tools andReview Instruments.Children (Basel, Switzerland) · 2023Review
- Validation of healthcare professional proxy-reported children's International Mucositis Evaluation Scale.Oral diseases · 2023Article
- Reliability and validity of proxy-SSPedi and mini-SSPedi in pediatric patients 2-7 years receiving cancer treatments.BMC cancer · 2022Article
- Prevalence and risk factors of oral mucositis in paediatric patients undergoing haematopoietic stem cell transplantation.Oral diseases · 2022Article
- Comparison of procalcitonin and C-reactive protein as early diagnostic marker for the identification of transplant-related adverse events after allogeneic hematopoietic stem cell transplantation in pediatric patients.Journal of cancer research and clinical oncology · 2019Article
- Article
- Review of a three-year study on the dental care of onco-hematological pediatric patients.Clinics (Sao Paulo, Brazil) · 2018Review
- Validation of the Symptom Screening in Pediatrics Tool in Children Receiving Cancer Treatments.Journal of the National Cancer Institute · 2018Article
- Guideline for the prevention of oral and oropharyngeal mucositis in children receiving treatment for cancer or undergoing haematopoietic stem cell transplantation.BMJ supportive & palliative care · 2017Review
- Literature review to assemble the evidence for response scales used in patient-reported outcome measures.Journal of patient-reported outcomes · 2017Review
- Refinement of the symptom screening in pediatrics tool (SSPedi).British journal of cancer · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundObjectives were to describe the reliability and validity of a new paediatric-specific mucositis scale, the Children's International Mucositis Evaluation Scale (ChIMES).
methodsIn a multi-centre prospective study, children aged 0 to ≤18 years were eligible if they were receiving any of the following: myeloablative stem cell transplantation (SCT), ≥60 mg m(-2) course(-1) doxorubicin or ≥12 g m(-2) methotrexate. Multiple measures of mucositis were included along with ChIMES. Respondents were parent proxy report for children aged <12 years, and child self-report for children aged 12-18 years and 8 to <12 years. Mucositis diaries were completed at baseline and on Days 7-17 following chemotherapy/conditioning. On Day 14, the respondent reported presence of mucositis and change since the previous day.
resultsThe 185 respondents included parents (N=98), children aged 12-18 years (N=66) and children aged 8 to <12 years (N=21). Test-retest reliability was excellent for ChIMES Total Score and ChIMES Percentage Score with r>0.8 for all respondent types. Criteria for construct validation were met across all measures. ChIMES also demonstrated responsiveness with significant differences between baseline and Day 14.
conclusionChIMES is a paediatric-specific measure of mucositis with favourable psychometric properties. It exhibits reliability, construct validity and responsiveness. ChIMES should be incorporated into clinical trials of mucositis prevention and treatment in paediatric cancer and SCT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.