ArticleBritish journal of cancer2013
Leukaemia incidence in the Techa River Cohort: 1953-2007.
Article in British journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 106 citations in OpenAlex.
- Epidemiological Studies of Low-Dose Ionizing Radiation and Cancer: Summary Bias Assessment and Meta-Analysis.Journal of the National Cancer Institute. Monographs · 2020Pooled it
- Epidemiological Studies of Low-Dose Ionizing Radiation and Cancer: Rationale and Framework for the Monograph and Overview of Eligible Studies.Journal of the National Cancer Institute. Monographs · 2020Pooled it
- Lymphoma and multiple myeloma in cohorts of persons exposed to ionising radiation at a young age.Leukemia · 2021Trial
- Development and validation of combined in vitro and in vivo assays for evaluating the efficacy of strontium-chelating compounds.Scientific reports · 2025Article
- Cancer Incidence and Childhood Residence Near the Coldwater Creek Radioactive Waste Site.JAMA network open · 2025Article
- Stochastic parametric skeletal dosimetry model for humans: Anatomical-morphological basis and parameter evaluation.PloS one · 2025Article
- Revisiting the Historic Strontium-90 Ingestion Beagle Study Conducted at the University of California Davis: Opportunity in Archival Materials.Radiation research · 2024Article
- A Historical Survey of Key Epidemiological Studies of Ionizing Radiation Exposure.Radiation research · 2024Review
- Article
- Radiation exposure and leukaemia risk among cohorts of persons exposed to low and moderate doses of external ionising radiation in childhood.British journal of cancer · 2023Article
- Radiation dose rate effects: what is new and what is needed?Radiation and environmental biophysics · 2022Review
- Hemophagocytic Lymphohistiocytosis in the Setting of Therapy-Induced Acute Myeloid Leukemia: An Autopsy Report.Diseases (Basel, Switzerland) · 2022Article
- Paediatric pre-B acute lymphoblastic leukaemia-derived exosomes regulate immune function in human T cells.Journal of cellular and molecular medicine · 2022Article
- Low-dose ionizing radiation exposure and risk of leukemia: results from 1950-1995 Chinese medical X-ray workers' cohort study and meta-analysis.Journal of the National Cancer Center · 2022Article
- Public health response and medical management of internal contamination in past radiological or nuclear incidents: A narrative review.Environment international · 2022Review
- Genetic Biomarkers and Their Clinical Implications in B-Cell Acute Lymphoblastic Leukemia in Children.International journal of molecular sciences · 2022Review
- Radiation cancer risk at different dose rates: new dose-rate effectiveness factors derived from revised A-bomb radiation dosimetry data and non-tumor doses.Journal of radiation research · 2022Article
- Possible relationship between mitochondrial changes and oxidative stress under low dose-rate irradiation.Redox report : communications in free radical research · 2021Article
- Article
- Occupational radiation and haematopoietic malignancy mortality in the retrospective cohort study of US radiologic technologists, 1983-2012.Occupational and environmental medicine · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundLittle is known about leukaemia risk following chronic radiation exposures at low dose rates. The Techa River Cohort of individuals residing in riverside villages between 1950 and 1961 when releases from the Mayak plutonium production complex contaminated the river allows quantification of leukaemia risks associated with chronic low-dose-rate internal and external exposures.
methodsExcess relative risk models described the dose-response relationship between radiation dose on the basis of updated dose estimates and the incidence of haematological malignancies ascertained between 1953 and 2007 among 28 223 cohort members, adjusted for attained age, sex, and other factors.
resultsAlmost half of the 72 leukaemia cases (excluding chronic lymphocytic leukaemia (CLL)) were estimated to be associated with radiation exposure. These data are consistent with a linear dose response with no evidence of modification. The excess relative risk estimate was 0.22 per 100 mGy. There was no evidence of significant dose effect for CLL or other haematopoietic malignancies.
conclusionThese analyses demonstrate that radiation exposures, similar to those received by populations exposed as a consequence of nuclear accidents, are associated with long-term dose-related increases in leukaemia risks. Using updated dose estimates, the leukaemia risk per unit dose is about half of that based on previous dosimetry.
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