ArticleJournal of neuroscience methods2014
Three-dimensional rodent motion analysis and neurodegenerative disorders.
Article in Journal of neuroscience methods, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Three-dimensional analysis of the characteristics of joint motion and gait pattern in a rodent model following spinal nerve ligation.Biomedical engineering online · 2021Article
- Analysis and Modeling of Rat Gait Biomechanical Deficits in Response to Volumetric Muscle Loss Injury.Frontiers in bioengineering and biotechnology · 2019Article
- In-silico experiments of zebrafish behaviour: modeling swimming in three dimensions.Scientific reports · 2017Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundThree-dimensional (3D) motion analysis is established in investigating, human pathological motion. In the field of gait, its use results in the objective identification of primary, and secondary causes of deviations, many current interventions are the result of pre- and post-testing, and it was shown recently that it can result in decreased number of surgeries and overall cost of care. Consequently, recent attempts have implemented 3D motion analysis using rat models to study, parkinsonism. However, to-date, a 3D user friendly analytical approach using rodent models to, identify etiologies of age-related motor impairment and accompanying pathologies has not been, implemented. NEW
methodWe have developed and presented all aspects of a 3D, three body-segment rodent model, to analyze motions of the lower, upper and head segments between rodents of parkinsonism-type and, normal aging during free walking. Our model does not require transformation matrices to describe the, position of each body-segment. Because body-segment positions are not considered to consist of three, rotations about the laboratory axes, the rotations are not sequence dependent.
resultsEach body-segment demonstrated distinct 3D movement patterns. The parkinsonism-type, genotype walked slower with less range of motion, similarly to patients with parkinsonism. COMPARISON WITH EXISTING
methodsThis is the first model considering the rodent's body as three, distinct segments. To the best of our knowledge, it is the first model to ever consider and report the 3D, head motion patterns.
conclusionsThis novel approach will allow unbiased analysis of spontaneous locomotion in mouse, models of parkinsonism or normal aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.