ReviewBiochimica et biophysica acta2014
Lipid abnormalities and lipid-based repair strategies in atopic dermatitis.
Review in Biochimica et biophysica acta, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03089476 (Hypothesis), which is not on this map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hypothesis: Skin Barrier Dysfunction With Altered Expression of Skin Barrier Proteins and Lipids Predicts Early Food Sensitizations in Infants at High Risk of Atopy
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Pooled it
- Emollients and moisturisers for eczema.The Cochrane database of systematic reviews · 2017Pooled it
- A daily regimen of a ceramide-dominant moisturizing cream and cleanser restores the skin permeability barrier in adults with moderate eczema: A randomized trial.Dermatologic therapy · 2021Trial
- Therapeutic responses toScience translational medicine · 2020Trial
- Lipid abnormalities in atopic skin are driven by type 2 cytokines.JCI insight · 2018Trial
- Skin Barrier Dysfunction in Contact and Atopic Dermatitis: A Comparative Review.Allergy, asthma & immunology research · 2026Review
- The Role of Ceramides in Metabolic and Cardiovascular Diseases.Journal of cardiovascular development and disease · 2026Review
- Mass Spectrometry Imaging Elucidates the Precise Localization and Site-Specific Functions of Skin Lipids.International journal of molecular sciences · 2025Article
- The epidermal lipid-microbiome loop and immunity: Important players in atopic dermatitis.Journal of advanced research · 2025Review
- Bleach baths enhance skin barrier, reduce itch but do not normalize skin dysbiosis in atopic dermatitis.Archives of dermatological research · 2023Article
- Baricitinib Lipid-Based Nanosystems as a Topical Alternative for Atopic Dermatitis Treatment.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Imaging-based evaluation of lipids in the stratum corneum by label-free stimulated Raman scattering microscopy.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023Article
- Effects of Indole-3-Lactic Acid, a Metabolite of Tryptophan, on IL-4 and IL-13-Induced Human Skin-Equivalent Atopic Dermatitis Models.International journal of molecular sciences · 2022Article
- An Interleukin-4 and Interleukin-13 Induced Atopic Dermatitis Human Skin Equivalent Model by a Skin-On-A-Chip.International journal of molecular sciences · 2022Article
- Skin Mast Cell-Driven Ceramides Drive Early Apoptosis in Pre-Symptomatic Eczema in Mice.International journal of molecular sciences · 2021Article
- On the surface: Skin microbial exposure contributes to allergic disease.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2020Review
- Article
- Non-invasive imaging in dermatology and the unique potential of raster-scan optoacoustic mesoscopy.Journal of the European Academy of Dermatology and Venereology : JEADV · 2019Review
- Epithelial barrier repair and prevention of allergy.The Journal of clinical investigation · 2019Review
- ELOVL4: Very long-chain fatty acids serve an eclectic role in mammalian health and function.Progress in retinal and eye research · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Prior studies have revealed the key roles played by Th1/Th2 cell dysregulation, IgE production, mast cell hyperactivity, and dendritic cell signaling in the evolution of the chronic, pruritic, inflammatory dermatosis that characterizes atopic dermatitis (AD). We review here increasing evidence that the inflammation in AD results primarily from inherited abnormalities in epidermal structural and enzymatic proteins that impact permeability barrier function. We also will show that the barrier defect can be attributed to a paracellular abnormality due to a variety of abnormalities in lipid composition, transport and extracellular organization. Accordingly, we also review the therapeutic implications of this emerging pathogenic paradigm, including several current and potentially novel, lipid-based approaches to corrective therapy. This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier. Guest Editors: Kenneth R. Feingold and Peter Elias.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.