ArticleBehavioral neuroscience2013
Hippocampus, time, and memory--a retrospective analysis.
Article in Behavioral neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed.
- No Clear Association between Impaired Short-Term or Working Memory Storage and Time Reproduction Capacity in Adult ADHD Patients.PloS one · 2015Trial
- Article
- A scalable hippocampal code for flexible interval timing through persistent activity.bioRxiv : the preprint server for biology · 2026Article
- Neural Representation of Episodic Time.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Time/Movement Estimation and Mental Rotation Tasks as Early Cognitive Markers in Alzheimer's Disease.Brain and behavior · 2025Article
- Review
- Mechanisms of impulsive choice: Experiments to explore and models to map the empirical terrain.Learning & behavior · 2023Review
- Temporal learning in the suprasecond range: insights from cognitive style.Psychological research · 2023Article
- Time Perception in Adult ADHD: Findings from a Decade-A Review.International journal of environmental research and public health · 2023Review
- The neural bases for timing of durations.Nature reviews. Neuroscience · 2022Review
- Mice expressing P301S mutant human tau have deficits in interval timing.Behavioural brain research · 2022Article
- KHSRP loss increases neuronal growth and synaptic transmission and alters memory consolidation through RNA stabilization.Communications biology · 2022Article
- A new paradigm for investigating temporal order memory shows higher order associations are present in recent but not in remote retrieval.Experimental brain research · 2022Article
- Medial Entorhinal Cortex Excitatory Neurons Are Necessary for Accurate Timing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Hippocampal Sequencing Mechanisms Are Disrupted in a Maternal Immune Activation Model of Schizophrenia Risk.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Do hippocampal pyramidal cells respond to nonspatial stimuli?Physiological reviews · 2021Review
- Is the scalar property of interval timing preserved after hippocampus lesions?Journal of theoretical biology · 2021Article
- Disorganization of Oscillatory Activity in Animal Models of Schizophrenia.Frontiers in neural circuits · 2021Review
- The Peak Interval Procedure in Rodents: A Tool for Studying the Neurobiological Basis of Interval Timing and Its Alterations in Models of Human Disease.Bio-protocol · 2020Article
- Navigating Through Time: A Spatial Navigation Perspective on How the Brain May Encode Time.Annual review of neuroscience · 2020Review
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Authors and funding
3 authors.
Funding
Abstract
In 1984, there was considerable evidence that the hippocampus was important for spatial learning and some evidence that it was also involved in duration discrimination. The article "Hippocampus, Time, and Memory" (Meck, Church, & Olton, 1984), however, was the first to isolate the effects of hippocampal damage on specific stages of temporal processing. In this review, to celebrate the 30th anniversary of Behavioral Neuroscience, we look back on factors that contributed to the long-lasting influence of this article. The major results were that a fimbria-fornix lesion (a) interferes with the ability to retain information in temporal working memory, and (b) distorts the content of temporal reference memory, but (c) did not decrease sensitivity to signal duration. This was the first lesion experiment in which the results were interpreted by a well-developed theory of behavior (scalar timing theory). It has led to extensive research on the role of the hippocampus in temporal processing by many investigators. The most important ones are the development of computational models with plausible neural mechanisms (such as the striatal beat-frequency model of interval timing), the use of multiple behavioral measures of timing, and empirical research on the neural mechanisms of timing and temporal memory using ensemble recording of neurons in prefrontal-striatal-hippocampal circuits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.