ArticleCOPD2014
Chronic productive cough is associated with death in smokers with early COPD.
Article in COPD, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- The Effect of Aclidinium on Symptoms Including Cough in Chronic Obstructive Pulmonary Disease: A Phase 4, Double-Blind, Placebo-controlled, Parallel-Group Study.American journal of respiratory and critical care medicine · 2019Trial
- Mucociliary Clearance in Former Tobacco Smokers with Both Chronic Obstructive Pulmonary Disease and Chronic Bronchitis and the Effect of Roflumilast.Journal of aerosol medicine and pulmonary drug delivery · 2019Trial
- Real-World Treatment Patterns and Patient-Reported Outcomes in Chronic Obstructive Pulmonary Disease in Japan: The REMIND Study.Advances in therapy · 2024Article
- Proportions and risk factors of chronic obstructive pulmonary disease and preserved ratio impaired spirometry, and association with small airway disease, in the positive screening older population from China: a cross-sectional study.BMC pulmonary medicine · 2024Article
- From treatable traits to GETomics in airway disease: moving towards clinical practice.European respiratory review : an official journal of the European Respiratory Society · 2024Review
- Comparison of newly diagnosed COPD patients and the non-COPD residents in Shanghai Minhang District.Frontiers in public health · 2023Article
- Impact of productive and dry chronic cough on mortality in the Canadian Longitudinal Study on Aging (CLSA).Journal of thoracic disease · 2022Article
- Impact of High-Density Urban Built Environment on Chronic Obstructive Pulmonary Disease: A Case Study of Jing'an District, Shanghai.International journal of environmental research and public health · 2019Article
- Weighing the evidence for pharmacological treatment interventions in mild COPD; a narrative perspective.Respiratory research · 2019Review
- Chronic Bronchitis: Where Are We Now?Chronic obstructive pulmonary diseases (Miami, Fla.) · 2019Article
- Clinical Practice Guidelines for Diagnosis and Management of Cough-Chinese Thoracic Society (CTS) Asthma Consortium.Journal of thoracic disease · 2018Review
- Risk factors predict frequent hospitalization in patients with acute exacerbation of COPD.International journal of chronic obstructive pulmonary disease · 2018Article
- Positive feedback of the amphiregulin-EGFR-ERK pathway mediates PM2.5 from wood smoke-induced MUC5AC expression in epithelial cells.Scientific reports · 2017Article
- Understanding the impact of symptoms on the burden of COPD.Respiratory research · 2017Review
- The Presence of Chronic Mucus Hypersecretion across Adult Life in Relation to Chronic Obstructive Pulmonary Disease Development.American journal of respiratory and critical care medicine · 2016Article
- Effect of aclidinium bromide on cough and sputum symptoms in moderate-to-severe COPD in three phase III trials.BMJ open respiratory research · 2016Article
- Sputum microbiology predicts health status in COPD.International journal of chronic obstructive pulmonary disease · 2016Observational
- Article
- Serum metalloproteinase-9 is related to COPD severity and symptoms - cross-sectional data from a population based cohort-study.Respiratory research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Cough and phlegm are common in COPD. Previous studies have shown conflicting evidence regarding their association with mortality and lung function. We sought to better understand how cough and phlegm impact mortality and lung function in COPD. We analyzed data from the Lung Health Study, consisting of 5,887 smokers with mild to moderate airflow obstruction followed longitudinally. We assessed the association between baseline symptoms of cough alone, phlegm alone, and cough and phlegm with 12.5-year mortality and annual lung function decline. Average age at entry was 48.5 years (± 6.8) with 63% males and 4% African Americans. Cough alone was present in 17%, phlegm alone in 12%, while 31% had both. Neither symptom alone was associated with death, but the combination was associated with increased risk of death after adjustment for age, gender, race, smoking status at year 5, pack-years smoked, randomization group, baseline FEV1 percent predicted (HR 1.27, 95% CI 1.02-1.59). Individuals with cough and phlegm together more commonly died of respiratory causes than those without. Cough with phlegm was associated with 48 mL lower baseline FEV1 (95% CI -90, -6), while neither symptom alone was associated with baseline FEV1. No symptom was associated with FEV1 longitudinally. Cough and phlegm together are associated with mortality and lung function decrement in mild-to-moderate COPD, independent of lung function and smoking status. Respiratory causes of death are common among those with cough and phlegm. Such information can help to identify subsets of individuals with COPD having higher risk for adverse outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.