ReviewJournal of internal medicine2013
Lessons from postgenome-wide association studies: functional analysis of cancer predisposition loci.
Review in Journal of internal medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Genomic Risk Factors for Cervical Cancer.Cancers · 2021Review
- Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element.American journal of human genetics · 2021Article
- Genetics of Polycystic Ovary Syndrome: What is New?Endocrinology and metabolism clinics of North America · 2021Review
- Elucidating the Underlying Functional Mechanisms of Breast Cancer Susceptibility Through Post-GWAS Analyses.Frontiers in genetics · 2018Review
- Quantifying deleterious effects of regulatory variants.Nucleic acids research · 2017Article
- Genetic susceptibility variants for lung cancer: replication study and assessment as expression quantitative trait loci.Scientific reports · 2017Article
- Functional characterization of a chr13q22.1 pancreatic cancer risk locus reveals long-range interaction and allele-specific effects on DIS3 expression.Human molecular genetics · 2016Article
- Enhancer scanning to locate regulatory regions in genomic loci.Nature protocols · 2016Article
- Functional analysis of the 11q23.3 glioma susceptibility locus implicates PHLDB1 and DDX6 in glioma susceptibility.Scientific reports · 2015Article
- Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.Nature genetics · 2015Article
- Genetic evidence for common pathways in human age-related diseases.Aging cell · 2015Article
- Human Enhancers Are Fragile and Prone to Deactivating Mutations.Molecular biology and evolution · 2015Article
- Multiple functional variants in long-range enhancer elements contribute to the risk of SNP rs965513 in thyroid cancer.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Incorporating computational resources in a cancer research program.Human genetics · 2015Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In the last few years, genome-wide association studies (GWASs) have identified hundreds of predisposition loci for several types of human cancers. Recent progress has been made in determining the underlying mechanisms through which different single-nucleotide polymorphisms (SNPs) affect predisposition to cancer. Although there has been much debate about the clinical utility of GWASs, less attention has been paid to how GWASs and post-GWASs functional analysis have contributed to understanding the aetiology of cancer. Most common variants associated with cancer risk are localized in nonprotein-coding regions highlighting transcriptional regulation as a common theme in the mechanism of cancer predisposition. Here, we outline strategies to functionally dissect predisposition loci and discuss their limitations as well as challenges for future studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.