ArticleBiomacromolecules2013
Electrospun blends of gelatin and gelatin-dendrimer conjugates as a wound-dressing and drug-delivery platform.
Article in Biomacromolecules, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Biocompatibility of Phosphorus Dendrimers and Their Antibacterial Properties as Potential Agents for Supporting Wound Healing.Molecular pharmaceutics · 2025Article
- Recent Progress in Multifunctional Stimuli-Responsive Combinational Drug Delivery Systems for the Treatment of Biofilm-Forming Bacterial Infections.Pharmaceutics · 2024Review
- Telodendrimer functionalized hydrogel platform for sustained antibiotics release in infection control.Acta biomaterialia · 2024Article
- Gelatin nanofibers: Recent insights in synthesis, bio-medical applications and limitations.Heliyon · 2023Review
- Local Drug Delivery Strategies towards Wound Healing.Pharmaceutics · 2023Review
- Regulatory perspectives of combination products.Bioactive materials · 2022Review
- State-of-the-Art Review of Electrospun Gelatin-Based Nanofiber Dressings for Wound Healing Applications.Nanomaterials (Basel, Switzerland) · 2022Review
- Nanotechnology Approaches in Chronic Wound Healing.Advances in wound care · 2021Review
- Exploring Dendrimer Nanoparticles for Chronic Wound Healing.Frontiers in medical technology · 2021Review
- Recent Advances in Nanomaterial-Based Wound-Healing Therapeutics.Pharmaceutics · 2020Review
- Review
- Electrospun PCL/mupirocin and chitosan/lidocaine hydrochloride multifunctional double layer nanofibrous scaffolds for wound dressing applications.International journal of nanomedicine · 2018Article
- Carboxymethyl chitosan nanoparticles loaded with bioactive peptide OH-CATH30 benefit nonscar wound healing.International journal of nanomedicine · 2018Article
- Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing.Advanced drug delivery reviews · 2018Review
- Progress in development of bioderived materials for dermal wound healing.Regenerative biomaterials · 2017Review
- Nanotechnology-Driven Therapeutic Interventions in Wound Healing: Potential Uses and Applications.ACS central science · 2017Review
- Biochemical and Biophysical Cues in Matrix Design for Chronic and Diabetic Wound Treatment.Tissue engineering. Part B, Reviews · 2017Article
- Polysaccharide Fabrication Platforms and Biocompatibility Assessment as Candidate Wound Dressing Materials.Bioengineering (Basel, Switzerland) · 2017Review
- Fabrication, characterization, and in vitro evaluation of silver-containing arabinoxylan foams as antimicrobial wound dressing.Journal of biomedical materials research. Part A · 2016Article
- Active Release of Nitric Oxide-Releasing Dendrimers from Electrospun Polyurethane Fibers.ACS biomaterials science & engineering · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In this work, we report a new nanofiber construct based on electrospun blends of gelatin and gelatin-dendrimer conjugates. Highly branched star-shaped polyamidoamine (PAMAM) dendrimer G3.5 was covalently conjugated to gelatin via EDC/NHS chemistry. Blends of gelatin and gelatin-dendrimer conjugates mixed with various loading levels of silver acetate (0, 0.83, 1.65, and 3.30% w/w) were successfully electrospun into nanofiber constructs (NCs). The NCs were further converted into semi-interpenetrating networks (sIPNs) with photoreactive polyethylene glycol diacrylate (Mn = 575 g mol(-1)) (PEG DA575). They were characterized in terms of fiber morphology, diameter, pore size, permeability, degradation, and mechanical properties. The resulting sIPN NCs retained nanofiber morphology, possessed similar fiber diameters to counterpart NCs, and gained improved structural stability. The sIPN NCs also showed good swelling capacity owing to porous structures and were permeable to aqueous solutions. Silver-containing sIPN NCs allowed sustained silver release and showed antimicrobial activity against two common types of pathogens, Staphylococcus aureus and Pseudomonas aeruginosa. Incorporation of dendrimers into the gelatin nanofibers through covalent conjugation not only expands drug loading capacity of nanofiber constructs but also provides tremendous flexibility for developing multifunctional electrospun dressing materials.
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Registered trials
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