ArticleProceedings of the National Academy of Sciences of the United States of America2013
Dynamic model for the coordination of two enhancers of broad by EGFR signaling.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Shared cis-regulatory modules control expression of the tandem paralogs midline and H15 in the follicular epithelium.Development (Cambridge, England) · 2022Article
- A Unifying Framework for Understanding Biological Structures and Functions Across Levels of Biological Organization.Integrative and comparative biology · 2022Article
- The ETS-transcription factor Pointed is sufficient to regulate the posterior fate of the follicular epithelium.Development (Cambridge, England) · 2020Article
- Two Drosophilids exhibit distinct EGF pathway patterns in oogenesis.Development genes and evolution · 2018Article
- Simple Expression Domains Are Regulated by Discrete CRMs DuringG3 (Bethesda, Md.) · 2017Article
- Gene regulation duringProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Epithelial Patterning, Morphogenesis, and Evolution: Drosophila Eggshell as a Model.Developmental cell · 2017Review
- BMP-dependent gene repression cascade in Drosophila eggshell patterning.Developmental biology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Although it is widely appreciated that a typical developmental control gene is regulated by multiple enhancers, coordination of enhancer activities remains poorly understood. We propose a mechanism for such coordination in Drosophila oogenesis, when the expression of the transcription factor Broad (BR) evolves from a uniform to a two-domain pattern that prefigures the formation of two respiratory eggshell appendages. This change reflects sequential activities of two enhancers of the br gene, early and late, both of which are controlled by the epidermal growth factor receptor (EGFR) pathway. The late enhancer controls br in the appendage-producing cells, but the function of the early enhancer remained unclear. We found that the early enhancer is essential for the activity of the late enhancer and induction of eggshell appendages. This requirement can be explained by a mechanism whereby the BR protein produced by the early enhancer protects the late enhancer from EGFR-dependent repression. We illustrate this complex mechanism using a computational model that correctly predicts the wild-type dynamics of BR expression and its response to genetic perturbations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.